Investigation of MDA-LDL (malondialdehyde-modified low-density lipoprotein) as a prognostic marker for coronary artery disease in patients with type 2 diabetes mellitus
| Autor: | Kenya Yamazaki, Masato Maekawa, Yoshitake Nakamura, Kazuo Kotani, Takashi Kanno, Jun Tashiro, Akira Miyazaki, Yasushi Saito, Hideaki Bujo |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Coronary Artery Disease Biochemistry Coronary artery disease chemistry.chemical_compound Percutaneous Coronary Intervention Restenosis Malondialdehyde Diabetes mellitus Internal medicine medicine Humans Aged business.industry Biochemistry (medical) Percutaneous coronary intervention Type 2 Diabetes Mellitus General Medicine Prognosis medicine.disease Lipoproteins LDL Diabetes Mellitus Type 2 chemistry Low-density lipoprotein Conventional PCI Cardiology Female lipids (amino acids peptides and proteins) business Biomarkers Lipoprotein |
| Zdroj: | Clinica Chimica Acta. 450:145-150 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2015.08.003 |
| Popis: | Background Although increased circulating levels of malondialdehyde-modified low-density lipoprotein (MDA-LDL) are associated with coronary artery disease (CAD), there is no direct evidence that increased MDA-LDL is a prognostic factor for CAD. Methods Forty-two patients (20 diabetic and 22 non-diabetic patients) who underwent percutaneous coronary intervention (PCI) were enrolled, and their baseline MDA-LDL levels were determined by immunoassay. Follow-up coronary angiography was performed at 2 to 7 months post-PCI. The patients were then divided into 2 groups, with in-stent restenosis (ISR) (n = 13) and without ISR (n = 29), and the baseline MDA-LDL levels were compared. We also studied 34 diabetics with CAD for up to 57 months until the onset of the next coronary event. Results In the diabetic patients, the mean MDA-LDL level was significantly higher in those with ISR than in those without ISR (151 +/− 61 vs. 90 +/− 26 U/l, p = 0.010). A baseline MDA-LDL value of 110 U/l for differentiating between diabetics with and without ISR was defined as the cut-off value. Kaplan–Meier analysis demonstrated that a circulating MDA-LDL of ≥ 110 U/l correlated significantly with a higher prevalence of cardiac events than MDA-LDL Conclusions Circulating MDA-LDL is a useful prognostic marker for future cardiac event in diabetic patients with CAD. |
| Databáze: | OpenAIRE |
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