Solid lipid nanoparticles: a review on recent perspectives and patents
| Autor: | Balak Das Kurmi, Rishi Paliwal, Shivani Rai Paliwal, Mukesh Kumar Sahu, Rameshroo Kenwat |
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| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Drug Carriers Chemistry Lipid nanocarriers Nanotechnology General Medicine Biocompatible material Lipids Patents as Topic Drug Delivery Systems Targeted drug delivery Drug Discovery Drug delivery Solid lipid nanoparticle Solid core Animals Humans Nanoparticles Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Expert Opinion on Therapeutic Patents. 30:179-194 |
| ISSN: | 1744-7674 1354-3776 |
| DOI: | 10.1080/13543776.2020.1720649 |
| Popis: | Introduction: Solid lipid nanoparticles (SLNs) are solid core lipid nanocarriers, which can hold both hydrophilic and hydrophobic drugs. They can be made up of biocompatible ingredients and therefore are one of the preferred choices for drug delivery. Surface modifications of SLNs may further provide unique features to them like mucoadhesiveness or targeting capability.Areas covered: In this review, the authors have covered areas from the basic introduction of SLNs to its applications in controlled drug delivery. More specifically, the authors have covered patents disclosed related to the SLNs for the period 2014-2019; however, a summary of patents of 2008-2013 is also included.Expert opinion: SLNs have been explored for development of compositions/formulations with improved therapeutics or cosmetic applications or for nutraceutical applications. Targeted SLNs compositions have been patented as evidenced from the literature; however, not such types of enough SLNs formulations have been claimed for the same. |
| Databáze: | OpenAIRE |
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