Mucosal administration of low-dose cell-associated feline immunodeficiency virus promotes viral latency
| Autor: | Barnabe Dossou Assogba, Mary Jo Burkhard, Sarah Leavell, Kyle Porter |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Feline immunodeficiency virus
Immunodeficiency Virus Feline Cat Diseases Virus Proviruses Virus latency medicine Immunology and Allergy Animals Viremia Disease Reservoirs CATS Mucous Membrane biology T lymphocyte biology.organism_classification medicine.disease Virology Virus Latency Disease Models Animal Infectious Diseases Lentivirus Immunology Vagina Cats Lentivirus Infections Female Ex vivo CD8 |
| Zdroj: | The Journal of infectious diseases. 195(8) |
| ISSN: | 0022-1899 |
| Popis: | Human immunodeficiency virus type 1 can occasionally be detected as a cryptic or latent infection in seronegative, asymptomatic patients. To develop an animal model of host latency, cats were mucosally challenged with 10(2)-10(6) feline immunodeficiency virus (FIV)-infected T cells. Although high-dose exposure (10(4)-10(6) T cells) resulted in progressive infection, no evidence of infection was seen in 5 of 6 cats exposed to 10(2) or 10(3) T cells. However, after ex vivo CD8(+) T cell depletion and phorbol myristate acetate treatment, FIV could be reactivated in tissues from 4 cats. Thus, latent tissue viral reservoirs can be induced by low-dose cell-associated mucosal challenge, providing a model to dissect the mechanisms that control reservoir establishment. |
| Databáze: | OpenAIRE |
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