Selectivity of finasteride as an in vivo inhibitor of 5 alpha-reductase isozyme enzymatic activity in the human prostate
| Autor: | Jack A. Schalken, Mark Feneley, Paul N. Span, Anthony G.H. Smals, Roger Kirby, M. Voller, Fred Sweep |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Urology Reductase urologic and male genital diseases Isozyme chemistry.chemical_compound Role of the 5 alpha-reductase isozyme type I in the human prostate and its relation with Benign Prostatic Hyperplasia (BHP) Prostate In vivo Internal medicine medicine business.industry De etiologie van benign prostaathyperplasie Hyperplasia medicine.disease Androgen The etiology of Benign Prostatic Hyperplasia Endocrinology medicine.anatomical_structure chemistry Dihydrotestosterone Finasteride De rol van het 5 alpha-reductase isozym type I in de humane prostaat en zijn betekenis voor het ontstaan van benigne prostaathyperplasie (BPH) business medicine.drug |
| Zdroj: | Journal of Urology, 161, pp. 332-337 Journal of Urology, 161, 332-337 |
| ISSN: | 0022-5347 |
| Popis: | The type II 5 alpha-reductase inhibitor finasteride is used in the treatment of benign prostatic hyperplasia (BPH), reducing local production of the growth promoting androgen dihydrotestosterone (DHT). The effect of prolonged treatment with this time-dependent irreversible inhibitor on the recently described prostatic type I 5 alpha-reductase, however, is not clear. Therefore, we assessed the effects of 5 mg. finasteride per day for 6 months on prostatic 5 alpha-reductase isozymes, and prostatic tissue composition and androgen content of patients suffering from BPH. In prostatic tissue from these patients, the type II enzymatic activity is inhibited 100-fold compared with tissues obtained from placebo treated patients. The type II immunoreactivity is up regulated 2-fold. The type I isozyme is inhibited 3-fold and potentially still contributes to DHT production. In conclusion, finasteride is a selective type II inhibitor in vivo. Further research is warranted to assess the possibly distinct roles o... |
| Databáze: | OpenAIRE |
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