Acral Pseudolymphomatous Angiokeratoma of Children
| Autor: | Hiroshi Koga, Yasutaka Tokuda, Fuyuko Arakura, Shigeo Kawachi, Kho Nakazawa, Hiroshi Murata |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Adolescent CD34 Dermatology Pathology and Forensic Medicine Lesion Young Adult Pseudolymphoma medicine Humans Membrane Glycoproteins business.industry Vascular malformation General Medicine medicine.disease Immunohistochemistry Angiokeratoma Cellular infiltration Lymphatic system Female medicine.symptom business Reticular Dermis |
| Zdroj: | The American Journal of Dermatopathology. 34:e128-e132 |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/dad.0b013e31824d679e |
| Popis: | Acral pseudolymphomatous angiokeratoma of children (APACHE) is characterized by multiple angiomatous papules on the hands and feet in children. Here, we report a case of APACHE in a female patient followed up from 13 to 19 years of age with a dark red lesion on the center of the dorsum of the right thigh. Histologically, vacuolar alteration and exocytosis of lymphocytes, and specific dense cellular infiltration beneath the epidermis to the reticular dermis were found. On immunolabeling study, the lesion vessels were found to be positive for both the lymphatic endothelium-specific marker podoplanin and blood vessel-specific marker CD34. These findings suggested that APACHE is a type of vascular malformation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|