Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools
| Autor: | Petr Dvorak, Alain Lacampagne, Albano C. Meli, Ivana Acimovic, Martin Pešl, Vladimír Rotrekl, Aleksandra Vilotić |
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| Rok vydání: | 2014 |
| Předmět: |
Pluripotent Stem Cells
Cell type lcsh:Medicine Review Article Germ layer 030204 cardiovascular system & hematology Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Humans Myocyte Myocytes Cardiac Induced pluripotent stem cell 030304 developmental biology 0303 health sciences General Immunology and Microbiology lcsh:R General Medicine Anatomy Stem Cell Research Embryonic stem cell In vitro Cell biology Stem cell Developmental biology |
| Zdroj: | BioMed Research International, Vol 2014 (2014) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2014/512831 |
| Popis: | Human pluripotent stem cells (hPSCs), namely, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), with their ability of indefinite self-renewal and capability to differentiate into cell types derivatives of all three germ layers, represent a powerful research tool in developmental biology, for drug screening, disease modelling, and potentially cell replacement therapy. Efficient differentiation protocols that would result in the cell type of our interest are needed for maximal exploitation of these cells. In the present work, we aim at focusing on the protocols for differentiation of hPSCs into functional cardiomyocytesin vitroas well as achievements in the heart disease modelling and drug testing on the patient-specific iPSC-derived cardiomyocytes (iPSC-CMs). |
| Databáze: | OpenAIRE |
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