Ectonucleotidases in the hippocampus: Spatial distribution and expression after ovariectomy and estradiol replacement

Autor:	Ivana Grković, Nataša Mitrović, Milorad Dragić
Rok vydání:	2022
Předmět:	Ectonucleotidases Adenosine Ecto-5′nucleotidase Estradiol Purinergic signaling NTPDase Hippocampus Synaptic modulation
Zdroj:	Vitamins and Hormones ISBN: 9780323992213 Vitamins and Hormones
DOI:	10.1016/bs.vh.2021.11.005
Popis:	Extracellular purine nucleotides, such as adenosine 5′-triphosphate (ATP), are important modulators of hippocampal function and plasticity. In the extracellular space, ATP is inherently short-lived molecule, which undergoes rapid enzymatic degradation to adenosine by ectonucleotidases. Given that ectonucleotidases have distinct and overlapping distribution in the hippocampus, and as ovarian hormones participate in a formation, maturation, and a refinement of synaptic contacts, both during development and in adulthood, the present chapter summarizes known data about spatial distribution of selected ecto-enzymes and estradiol-induced effects on ectonucleotidases in the rat hippocampus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2191390afef5c55806de881ea6902f84 https://doi.org/10.1016/bs.vh.2021.11.005 Zobrazit plný text záznamu