Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes

Autor: E. Vandemeulebroucke, P. De Pauw, F. K. Gorus, Ogonnaya C. Ubani, Rui Mao, I. Truyen, C. Van Schravendijk, K. Decochez, I Weets, Daniel Pipeleers, P. N. Jørgensen
Přispěvatelé: Pathologic Biochemistry and Physiology, Electrical Engineering and Power Electronics, Department of Bio-engineering Sciences, Ultrastructure, Structural Biology Brussels, Experimental Pharmacology
Rok vydání: 2005
Předmět:
Male
endocrine system diseases
Endocrinology
Diabetes and Metabolism
Prohormone
medicine.disease_cause
HLA-DQ Antigens/genetics
Autoimmunity
chemistry.chemical_compound
Child
Proinsulin
C-Peptide
biology
C-peptide
Middle Aged
Pedigree
C-Peptide/blood
Female
Antibody
hormones
hormone substitutes
and hormone antagonists
medicine.drug
Adult
endocrine system
medicine.medical_specialty
Child
preschool
digestive system
Prediabetic State
Islets of Langerhans
Predictive Value of Tests
HLA-DQ Antigens
Internal medicine
HLA-DQ
Internal Medicine
medicine
Humans
Islets of Langerhans/immunology
Autoantibodies
Type 1 diabetes
Prediabetic State/diagnosis
Infant
Newborn
Autoantibody
Infant
nutritional and metabolic diseases
Diabetes Mellitus
Type 1/blood
medicine.disease
Hormones
Hormones/blood
Proinsulin/blood
Diabetes Mellitus
Type 1
Endocrinology
chemistry
Immunology
biology.protein
Autoantibodies/blood
Zdroj: Diabetologia. 48:2322-2329
ISSN: 1432-0428
0012-186X
DOI: 10.1007/s00125-005-1959-0
Popis: AIMS/HYPOTHESIS: We investigated whether random proinsulin levels and proinsulin:C-peptide ratio (PI:C) complement immune and genetic markers for identifying relatives at high risk of type 1 diabetes. MATERIALS AND METHODS: During an initial sampling, random glycaemia, proinsulin, PI:C and HLA DQ genotype were determined in 561 non-diabetic first-degree relatives who had been positive for islet autoantibodies on one or more occasions and in 561 age- and sex-matched persistently antibody-negative relatives. RESULTS: During follow-up (median 62 months), 46 relatives with antibodies at entry developed type 1 diabetes. At baseline, antibody-positive relatives (n=338) had higher PI:C values (p
Databáze: OpenAIRE
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