A correlation study between blink reflex habituation and clinical state in patients with Parkinson's disease
| Autor: | Hiroshi Noro, Yukiko Yanada, Susumu Chiba, Hiroyuki Matsumoto, Yumiko Motoi, Nagako Miyano, Yuh Kaneshige |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Parkinson's disease Stimulation Antiparkinson Agents Dysarthria Reference Values Activities of Daily Living medicine Humans Corneal reflex Habituation Habituation Psychophysiologic Blinking Parkinson Disease Middle Aged Supraorbital nerve medicine.disease Electric Stimulation Neurology Dyskinesia Anesthesia Physical therapy Reflex Neurology (clinical) medicine.symptom Psychology |
| Zdroj: | Journal of the Neurological Sciences. 107:155-159 |
| ISSN: | 0022-510X |
| Popis: | The neurologic states and activities of daily life of patients with Parkinson's disease were evaluated using a rating scale with subitems, and subsequently the neurologic disturbance scores and the daily activity impairment scores were obtained. Subjects consisted of 19 normal controls, and 55 ambulatory patients without marked dyskinesia who were on various anti-parkinsonian drugs. Blink reflex was elicited by paired electrical stimulation over the supraorbital nerve. The interval time between the conditioning stimulation and the test stimulation was set at 200 ms, and 5 serial ipsilateral maximal R2 amplitudes on the stimulated side were measured. The mean of the paired maximal R2 amplitude ratio (test/conditioning), expressed as a percentage, was defined as the habituation index. The habituation indices in normal controls and those with Parkinson's disease were 17.1 +/- 7.6 and 51.9 +/- 29.3, respectively (P less than 0.01). The degree of akinesia, rigidity, balance/gait and dysarthria was positively correlated with the habituation index (P less than 0.01), while tremor was not. On the whole the habituation index was found to have a significant correlation not only with the neurologic disturbance score but also with the daily activity impairment score (P less than 0.01). |
| Databáze: | OpenAIRE |
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