United Kingdom Multicentre Acamprosate Study (UKMAS): a 6-month prospective study of acamprosate versus placebo in preventing relapse after withdrawal from alcohol
| Autor: | Bruce Ritson, Jonathan Chick, Marsha Y. Morgan, Harry Howlett |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Adolescent Visual analogue scale Taurine media_common.quotation_subject Acamprosate Craving Anxiety Placebo Severity of Illness Index law.invention Randomized controlled trial law Secondary Prevention Medicine Humans Prospective Studies Adverse effect Prospective cohort study media_common Aged Dose-Response Relationship Drug business.industry Depression General Medicine Abstinence Middle Aged Alcoholism Treatment Outcome Anesthesia Patient Compliance Female medicine.symptom Safety business medicine.drug Alcohol Deterrents |
| Zdroj: | Alcohol and alcoholism (Oxford, Oxfordshire). 35(2) |
| ISSN: | 0735-0414 |
| Popis: | A 6-month randomized controlled study of acamprosate versus placebo in preventing relapse following withdrawal from alcohol was undertaken in 20 centres throughout the UK. Patients diagnosed as alcohol-dependent and detoxified within the preceding 5 weeks were randomly assigned to treatment with either acamprosate (A) 666 mg three times/day or identical placebo (P). A total of 664 patients were screened; 581 were entered into the treatment phase. One-third were episodic drinkers, 84% were male, 44% were unmarried and 48% were unemployed. Medication was first taken on average 24 days after the start of detoxification; 32% of patients had already relapsed by this time. The 6-month study period was completed by 35% of patients; adverse events led to withdrawal of a further 14% (A) and 9% (P) respectively. Compliance was poor in that, by the end of the second week, only 57% of patients were judged to be taking at least 90% of their tablets. The mean total of abstinent days achieved was 77 (A) and 81 (P). Complete abstinence for 6 months was achieved by 12% (A) and 11% (P); drinking remained within controlled limits in a further 3% (A) and 6% (P). An effect of acamprosate on consumption was not seen when subgroups, including those defined by the Lesch typology, were analysed separately. However, the mean percentage reduction in craving for alcohol measured on a visual analogue scale was greater in the acamprosate, than placebo, patients at week 2 and week 4 (P |
| Databáze: | OpenAIRE |
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