Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls
| Autor: | Robert J. Wyatt, John T. Sanders, Zoran Bursac, M. Colleen Hastings, Jan Novak, Zina Moldoveanu, Bruce A. Julian |
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| Rok vydání: | 2017 |
| Předmět: |
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medicine.medical_specialty Elevated level Article Subject 030232 urology & nephrology chemical and pharmacologic phenomena Disease 030204 cardiovascular system & hematology lcsh:RC870-923 urologic and male genital diseases Gastroenterology Nephropathy 03 medical and health sciences 0302 clinical medicine fluids and secretions stomatognathic system Internal medicine medicine business.industry Pathogenic factor Repeated measures design medicine.disease lcsh:Diseases of the genitourinary system. Urology Nephrology Potential biomarkers Immunology Analysis of variance business Research Article |
| Zdroj: | International Journal of Nephrology International Journal of Nephrology, Vol 2017 (2017) |
| ISSN: | 2090-214X |
| Popis: | Galactose-deficient IgA1 (Gd-IgA1) is a key pathogenic factor for IgA nephropathy (IgAN) and a potential biomarker for the disease. This study examined serial serum Gd-IgA1 levels over 1 year in 13 children with IgAN and 40 healthy children, to determine whether or not serum Gd-IgA1 levels changed over time. Subjects were younger than 18 years of age. Follow-up measurements were scheduled 6 and/or 12 months later. Analysis of variance and regression models for repeated measures were used to estimate group and time effects. Serum Gd-IgA1 level was higher in initial samples for IgAN patients compared to those of healthy children(P<0.0001). Serum Gd-IgA1 levels did not change over time for healthy controls but increased for IgAN patients(P=0.001). Serum Gd-IgA1 level was elevated for 9 children with IgAN at study entry and remained elevated. Two of the 4 IgAN patients with initially normal Gd-IgA1 levels had a subsequent elevated level. The persistent elevation of the serum Gd-IgA1 level in children with IgAN enhances its utility as a potential diagnostic test for IgAN. |
| Databáze: | OpenAIRE |
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