The risk of pancreatic cancer in symptomatic patients in primary care: a large case-control study using electronic records
| Autor: | Sally Stapley, Fiona M Walter, Richard D Neal, William Hamilton, Peter W Rose, Tim J Peters |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Diarrhea Male Risk Cancer Research medicine.medical_specialty Abdominal pain Nausea Vomiting diagnosis pancreatic cancer MEDLINE Jaundice Gastroenterology primary care Pancreatic cancer Internal medicine positive predictive values Weight Loss medicine Humans Aged Aged 80 and over Primary Health Care business.industry Case-control study Cancer Odds ratio Middle Aged medicine.disease Abdominal Pain Pancreatic Neoplasms Oncology Databases as Topic Back Pain Case-Control Studies Clinical Study symptoms Female medicine.symptom business Constipation |
| Zdroj: | British Journal of Cancer |
| DOI: | 10.1038/bjc.2012.190 |
| Popis: | Background: Over 8000 new pancreatic cancers are diagnosed annually in the UK; most at an advanced stage, with only 3% 5-year survival. We aimed to identify and quantify the risk of pancreatic cancer for features in primary care. Methods: A case-control study using electronic primary care records identified and quantified the features of pancreatic cancer. Cases, aged ≥ 40 in the General Practice Research Database, UK, with primary pancreatic cancer were matched with controls on age, sex and practice. Putative features of pancreatic cancer were identified in the year before diagnosis. Odds ratios (OR) were calculated for features of cancer using conditional logistic regression. Positive predictive values (PPV) were calculated for consulting patients. Results: In all, 3635 cases and 16 459 controls were studied. Nine features were associated with pancreatic cancer (all P1%. Conclusion: Most previously reported symptoms of pancreatic cancer were also relevant in primary care. Although predictive values were small-apart from jaundice-they provide a basis for selection of patients for investigation, especially with multiple symptoms. © 2012 Cancer Research UK All rights reserved. |
| Databáze: | OpenAIRE |
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