Progelatinase B/matrix metalloproteinase-9 proenzyme as a marker of pleural inflammation

Autor:	Petr Puzman, David Havel, Jaromir Kotyza, Miloš Pešek
Rok vydání:	2004
Předmět:	Pulmonary and Respiratory Medicine Male medicine.medical_specialty Pathology medicine.medical_treatment Clinical Biochemistry Inflammation Proinflammatory cytokine Lesion Leukocyte Count Internal medicine Thoracoscopy medicine Humans Respiratory system Interleukin 6 Molecular Biology Pleurodesis Aged chemistry.chemical_classification Enzyme Precursors medicine.diagnostic_test biology L-Lactate Dehydrogenase business.industry Interleukin-6 Metalloendopeptidases Middle Aged Pleural Effusion Enzyme Endocrinology Cytokine C-Reactive Protein Treatment Outcome chemistry Matrix Metalloproteinase 9 Gelatinases Talc biology.protein Pleura Female medicine.symptom business Biomarkers
Zdroj:	Experimental lung research. 30(4)
ISSN:	0190-2148
Popis:	Previous analyses of pleural effusions of different origin revealed high levels of matrix metalloproteinase-9 proenzyme (proMMP-9), predominantly in parainfectious exudates. To confirm the etiological association with inflammation and to explore time course of release of proMMP-9 under conditions of a local inflammatory reaction, the authors estimated proMMP-9 in pleural fluids of patients undergoing therapeutic talc pleurodesis (n = 20) and explorative thoracoscopy (n = 4), before, and at different time intervals after the intervention. The authors also compared proMMP-9 values with proinflammatory markers, such as interleukin-6 (IL-6), C-reactive protein (CRP), and leukocyte count. As revealed through scanning substrate electrophoresis, proMMP-9 levels increased within the first hours a!nd culminated 16 to 48 hours after intervention, amounting to 1.5- to 102 -fold of initial concentration (mean = 14.8 -fold). MMP-9 proenzyme values significantly correlated with the levels of proinflammatory cytokine IL-6 (r =.79, n = 47, p.01) and with neutrophil counts (r =.75, n = 45, p.01). In conclusion, the results present proMMP-9 as a novel early indicator of acute host-response in pleural space that complements traditional proinflammatory markers and might be useful in monitoring pleural inflammatory processes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2188dd27ef449dd6be2c71b0ebf38a52 https://pubmed.ncbi.nlm.nih.gov/15204835 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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