Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads
| Autor: | Theodore Sentoukas, Vangelis Karalis, Efstratia Goula, Marilena Vlachou, Natassa Pippa, Panagiotis Georgas, Angeliki Siamidi, Stergios Pispas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Sleep Wake Disorders
Thermogravimetric analysis Calcium alginate Alginates Drug Compounding Chronobiotic in vitro release Pharmaceutical Science melatonin 02 engineering and technology 01 natural sciences Melatonin chemistry.chemical_compound medicine swelling behavior Thermal stability hydrogels calcium alginate beads thermogravimetric analysis Pharmaceutical industry Pharmacology Drug Carriers Molecular mass Viscosity 010405 organic chemistry Chemistry General Medicine Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology 0104 chemical sciences Molecular Weight Drug Liberation Kinetics Thermogravimetry Self-healing hydrogels Biophysics Swelling medicine.symptom HD9665-9675 0210 nano-technology medicine.drug |
| Zdroj: | Acta Pharmaceutica, Vol 70, Iss 4, Pp 527-538 (2020) Acta Pharmaceutica Volume 70 Issue 4 |
| ISSN: | 1846-9558 1330-0075 |
| Popis: | A variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, which incorporate the chronobiotic hormone melatonin (MLT). The in vitro release of the hormone in aqueous media at pH 1.2 and 6.8 was probed in the conjunction with the swelling of the beads and their thermal degradation properties. It has been found that the release of MLT from the beads was reversibly proportional to the extent of their expansion, which depends on the molecular mass/viscosity of the biopolymers present in the beads; the higher the molecular mass/viscosity of the hydrogels the greater the beads swelling and the less the MLT’s release. Thermogravimetric analysis (TGA) data support the presence of the components in the hybrid hydrogel beads and elucidate their effects on the thermal stability of the systems. Thus, the physicochemical properties of the biopolymers used, along with their stereoelectronic features modulate the release of MLT from the beads, providing formulations able to treat sleep onset related problems or dysfunctions arising from poor sleep maintenance. |
| Databáze: | OpenAIRE |
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