Oculomotor Areas of the Primate Frontal Lobes: A Transneuronal Transfer of Rabies Virus and [14C]-2-Deoxyglucose Functional Imaging Study
| Autor: | W. Graf, Kostas Hadjidimitrakis, M. Doldan, Adonis K. Moschovakis, Gabriella Ugolini, Georgia G. Gregoriou, W. Guldin, Helen E. Savaki |
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| Přispěvatelé: | Moschovakis A.K., Gregoriou G.G., Ugolini G., Doldan M., Graf W., Guldin W., Hadjidimitrakis K., Savaki H.E., Department of Basic Sciences, University of Crete [Heraklion] (UOC)-Faculty of Medicine, Laboratoire de neurobiologie cellulaire et moléculaire (NBCM), Centre National de la Recherche Scientifique (CNRS), Institut de Neurobiologie Alfred Fessard (INAF), Laboratoire de Physiologie de la Perception et de l'Action (LPPA), Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), Department of Psychology, University of Landau |
| Rok vydání: | 2004 |
| Předmět: |
Cingulate cortex
Supplementary eye field genetic structures [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology MESH: Frontal Lobe 0302 clinical medicine Cortex (anatomy) Neural Pathways MESH: Animals Motor Neurons 0303 health sciences General Neuroscience Anatomy MESH: Rabies virus Frontal Lobe MESH: Oculomotor Muscles medicine.anatomical_structure Frontal lobe Saccade MESH: Saccades [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female Psychology Frontal eye field MESH: Motor Neurons Oculomotor Behavioral/Systems/Cognitive Fixation Ocular Deoxyglucose Motor Neuron MESH: Macaca mulatta Premotor cortex Neural Pathway 03 medical and health sciences Saccades medicine Animals MESH: Fixation Ocular Macaca fasciculari 030304 developmental biology Animal principal sulcus MESH: Neural Pathways Lateral rectus muscle Eye movement MESH: Deoxyglucose Macaca mulatta Macaca fascicularis Oculomotor Muscle MESH: Macaca fascicularis Cingulate eye field Principal sulcu cingulate eye fields Oculomotor Muscles Rabies virus Orbitofrontal cortex MESH: Female Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroscience Journal of Neuroscience, Society for Neuroscience, 2004, 24 (25), pp.5726-5740. ⟨10.1523/JNEUROSCI.1223-04.2004⟩ |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.1223-04.2004 |
| Popis: | We used the [14C]-2-deoxyglucose method to study the location and extent of primate frontal lobe areas activated for saccades and fixation and the retrograde transneuronal transfer of rabies virus to determine whether these regions are oligosynaptically connected with extraocular motoneurons. Fixation-related increases of local cerebral glucose utilization (LCGU) values were found around the fundus of the inferior limb of the arcuate sulcus (AS) just ventral to its genu, in the dorsomedial frontal cortex (DMFC), cingulate cortex, and orbitofrontal cortex. Significant increases of LCGU values were found in and around both banks of the AS, DMFC, and caudal principal, cingulate, and orbitofrontal cortices of monkeys executing visually guided saccades. All of these areas are oligosynaptically connected to extraocular motoneurons, as shown by the presence of retrogradely transneuronally labeled cells after injection of rabies virus in the lateral rectus muscle. Our data demonstrate that the arcuate oculomotor cortex occupies a region considerably larger than the classic, electrical stimulation-defined, frontal eye field. Besides a large part of the anterior bank of the AS, it includes the caudal prearcuate convexity and part of the premotor cortex in the posterior bank of the AS. They also demonstrate that the oculomotor DMFC occupies a small area straddling the ridge of the brain medial to the superior ramus of the AS. Our results support the notion that a network of several interconnected frontal lobe regions is activated during rapid, visually guided eye movements and that their output is conveyed in parallel to subcortical structures projecting to extraocular motoneurons. |
| Databáze: | OpenAIRE |
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