Efficacy of early use of remdesivir: a systematic review of subgroup analysis
| Autor: | Gil Sierra, Manuel David, Briceño Casado, María del Pilar, Alegre del Rey, Emilio Jesús, Sánchez Hidalgo, Marina |
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| Přispěvatelé: | Universidad de Sevilla. Departamento de Farmacología |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | idUS. Depósito de Investigación de la Universidad de Sevilla instname |
| Popis: | Introduction A possible benefit has been suggested for early treatment of severe coronavirus disease 2019 (COVID-19) with remdesivir. The efficacy of this drug is controversial and could significantly influence the efficiency in healthcare systems. The objective is the methodological interpretation of subgroup analyzes according to starting of remdesivir treatment with respect to symptom onset of COVID-19. Methods A search in Pubmed® database was performed. Randomized clinical trials (RCTs) with subgroup analysis regarding early and late use of remdesivir were selected. All endpoints were assessed using two methodologies. First methodology considered statistical interaction, pre-specification, biological plausibility, and consistency of results. Second methodology was a validated tool with preliminary questions to discard subset analysis without relevant minimum conditions, and a checklist with recommendations for applicability. Results A total of 54 results were found and five RCTs were selected. According first methodology, consistent heterogeneity was only found in time to clinical improvement and better clinical status score at day 15 for patients with severe COVID-19 and |
| Databáze: | OpenAIRE |
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