Expression of proliferation markers Ki67, cyclin A, geminin and aurora-kinase A in primary breast carcinomas and corresponding distant metastases
| Autor: | Eszter Turányi, A. Marcell Szász, Zoltán Hanzély, Lilla V. Lukács, Gabriella Arató, Janina Kulka, István Kenessey, Anna Maria Tokes, János Fillinger, Katalin Bálint, Nora Meggyeshazi, Miklos Szendroi, István Arthur Molnár, Ibolya Soltesz, Franciska Geszti |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Metastatic breast Pathology medicine.medical_specialty Lung Neoplasms Time Factors Cyclin A Bone Neoplasms Breast Neoplasms Kaplan-Meier Estimate Disease-Free Survival Pathology and Forensic Medicine Central Nervous System Neoplasms Breast cancer Predictive Value of Tests Risk Factors medicine Humans Aged Aurora Kinase A Cell Proliferation Retrospective Studies Aged 80 and over Hungary Lung biology Carcinoma Geminin General Medicine Middle Aged medicine.disease Immunohistochemistry Ki-67 Antigen medicine.anatomical_structure Tissue Array Analysis Cancer research Ki67 index biology.protein Female |
| Zdroj: | Journal of Clinical Pathology. 68:274-282 |
| ISSN: | 1472-4146 0021-9746 |
| Popis: | AimsTo assess the expression of the following cell cycle regulatory proteins in primary metastatic breast carcinomas (MBCs) and on availability in matched distant metastases (DMs): Ki67, cyclin A, geminin and aurora-kinase A (aurkA); and to compare the expression of these markers in early MBC (EMBC) and late MBC separated into groups according to median time point on metastatic event occurred (28 months).MethodsThe expression of the above mentioned markers was analysed in a total of 47 primary MBCs and 59 DMs (out of which 37 were pairs) by immunohistochemistry. Fourteen breast carcinomas with no relapse over a 10-year follow-up period were utilised as control cases (CBC).ResultsAmong the MBCs, 22 metastasised to the bone, 4 to the lung and 21 to the central nervous system (CNS). Geminin (pConclusionsKi67 index and geminin distinguish a fraction of MBC with worse prognosis, showing increased levels in the latter in comparison to CBC being tumour-free over a 10-year follow-up period. Ki67 could possibly identify a group of MBCs that develop early DMs. |
| Databáze: | OpenAIRE |
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