Oral treatment of transmissible gastroenteritis with natural human interferon alpha: A field study
| Autor: | Alan B. Richards, Joseph M. Cummins, David P. Hutcheson, Richard E. Mock, Steven Krakowka, Bradford W. Shive |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Oral treatment Swine animal diseases Immunology Physiology Administration Oral Alpha interferon Placebo Biochemistry Article Disease Outbreaks High morbidity Animals Immunology and Allergy Medicine Beneficial effects Molecular Biology Natural course General Veterinary Gastroenteritis Transmissible of Swine business.industry Outbreak Interferon-alpha Hematology Prognosis Texas Virology Survival Rate Animals Newborn Female business |
| Zdroj: | Veterinary Immunology and Immunopathology |
| ISSN: | 0165-2427 |
| DOI: | 10.1016/0165-2427(94)05351-r |
| Popis: | During a natural outbreak of transmissible gastroenteritis (TGE), groups of piglets were treated orally for 4 consecutive days with placebo or 1.0, 10.0 or 20.0 international units (IU) natural human interferon alpha (nHuIFN alpha). Piglets that were 1-12 days of age and given 1.0, 10.0 or 20.0 IU nHuIFN alpha had significantly (P0.01) greater survival rates than placebo-treated piglets; survival rates were the greater for the highest level of nHuIFN alpha treatment. In contrast, beneficial effects of nHuIFN alpha were not observed in piglets farrowed during the disease outbreak and given nHuIFN alpha within hours of birth. Oral nHuIFN alpha therapy modulates the natural course of high morbidity and mortality commonly seen with TGE. |
| Databáze: | OpenAIRE |
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