The Peritoneal Macrophages in Inflammatory Diseases and Abdominal Cancers
| Autor: | Lei-Wen Peng, Li Chang, Yongmei Jiang, Ting Liu, Fang Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Cancer Research
Cell type medicine.medical_treatment Peritoneal macrophages (PMs) Inflammation Review Inflammatory diseases 030226 pharmacology & pharmacy Abdominal cancers Proinflammatory cytokine 03 medical and health sciences Peritoneal cavity 0302 clinical medicine medicine Humans Abdominal Neoplasms Innate immune system business.industry General Medicine Immunotherapy Acquired immune system medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Immunology Macrophages Peritoneal medicine.symptom business |
| Zdroj: | Oncology Research |
| ISSN: | 1555-3906 0965-0407 |
| Popis: | Peritoneal macrophages (PMs) are the major cell type of peritoneal cells that participate in multiple aspects of innate and acquired immunity in the peritoneal cavity. PMs have an ability to release a large amount of proinflammatory and anti-inflammatory cytokines and therefore play a critical role in regulating the differentiation of innate immune cells and inflammatory T cells. Accumulating studies demonstrate that the immunological reactions and inflammatory responses of PMs are strongly related to the pathogenic processes of various inflammatory diseases and abdominal cancers. Consequently, the regulation of PM activation has gradually emerged as a promising target for immunotherapy, and better understanding of the distinctly biological function of PMs in individual diseases is crucial for designing specific and effective therapeutic agents. This review covers the characterization and immunological function of PMs in hosts with inflammatory diseases and abdominal cancers. |
| Databáze: | OpenAIRE |
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