Macroprolactinemia: the consequences of a laboratory pitfall
| Autor: | Erzsébet Toldy, István Szabolcs, Gábor L. Kovács, Miklós Góth, Pál Kneffel, Zoltan Locsei, Dominika Szöke |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Prolactin blood Fractional Precipitation Macroprolactin Gastroenterology Prolactin Polyethylene Glycols Hyperprolactinemia Endocrinology Internal medicine Luminescent Measurements medicine Humans Female business Child hormones hormone substitutes and hormone antagonists Retrospective Studies |
| Zdroj: | Endocrine. 22(3) |
| ISSN: | 1355-008X |
| Popis: | The objective of this study was to assess the prevalence of macroprolactin, a macromolecule with reduced bioactivity, in hyperprolactinemic patients. Prolactin was measured before and after precipitation of macroprolactin by polyethylene glycol in 306 patients. Only patients with prolactin values700 mIU/L (n = 270) entered the study. In 23% of the patients, macroprolactinemia was found. In women, the occurrence of macroprolactinemia increased with advancing age (30 yr: 16%; 30-45 yr: 28%;45 yr: 42%; p0.05). A priori clinical signs of hyperprolactinemia (morphological abnormalities in pituitary imaging, galactorrhea infertility) occurred significantly less frequently in macroprolactinemia than in true hyperprolactinemia. In eight females macroprolactinemia and true hyperprolactinemia appeared simultaneously. To avoid diagnostic and therapeutic pitfalls, the screening for macroprolactinemia of all patients with prolactin levels of700 mIU/ L is recommended. |
| Databáze: | OpenAIRE |
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