Human fetal microglia acquire homeostatic immune-sensing properties early in development
| Autor: | Jon D. Laman, Nieske Brouwer, Susanne M. Kooistra, Laura Kracht, Sharon Eskandar, Jelmer R. Prins, Sicco A. Scherjon, S M Chuva de Sousa Lopes, Bart J. L. Eggen, Malte Borggrewe |
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| Přispěvatelé: | Translational Immunology Groningen (TRIGR), Molecular Neuroscience and Ageing Research (MOLAR), Reproductive Origins of Adult Health and Disease (ROAHD), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE) |
| Rok vydání: | 2019 |
| Předmět: |
Central nervous system
Embryonic Development Cell Separation Biology Transcriptome Immune system AGE Fetus Phagocytosis BINDING medicine Humans Gene Regulatory Networks RNA-SEQ Cells Cultured Multidisciplinary Microglia PU.1 Brain Phenotype Chromatin READ ALIGNMENT medicine.anatomical_structure DIFFERENTIATION MYELINOGENESIS nervous system CELLS Myelinogenesis TURNOVER Neuroscience |
| Zdroj: | Science, 369(6503), 530-+. AMER ASSOC ADVANCEMENT SCIENCE Science, 369(6503), 530-537. AMER ASSOC ADVANCEMENT SCIENCE |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | The development of microglia Microglia are the brain's immune cells, and they play important roles in health and neurodegenerative disease. Kracht et al. performed single-cell analysis of human microglial gene expression and chromatin accessibility and compared the results with those of other studies of human and mice microglial development. By using in situ validation, these data identify fetal microglial subsets that appear to be distinct from adult human microglia, suggesting functional differences between the developing and mature brain. Science , this issue p. 530 |
| Databáze: | OpenAIRE |
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