Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus
| Autor: | Xinyan Ni, Cuicui Gao, Yiqing Yang, Yan Xiao, Fang Luo, Wei L. Shen, Qian Zhou, Jiajun Yang, Yuling Mu |
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| Rok vydání: | 2019 |
| Předmět: |
Biology
Mice 03 medical and health sciences 0302 clinical medicine Genetics medicine Biological neural network Animals Lateral parabrachial nucleus Molecular Biology 030304 developmental biology Neurons Nucleus raphe magnus 0303 health sciences Brain-Derived Neurotrophic Factor Subiculum Axons Preoptic area Anterograde tracing medicine.anatomical_structure nervous system Synapses Zona incerta Neuroscience Nucleus 030217 neurology & neurosurgery Paraventricular Hypothalamic Nucleus |
| Zdroj: | Journal of Genetics and Genomics. 46:31-40 |
| ISSN: | 1673-8527 |
| Popis: | Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that might provide inputs to or receive inputs from the paraventricular nucleus (PVN) BDNF neurons, a key type of cells in regulating feeding and thermogenesis, we used rabies virus-based transsynaptic labeling and adeno-associated virus based anterograde tracing techniques to reveal their whole-brain distributions. We found that dozens of brain regions provide dense inputs to or receive dense inputs from PVN BDNF neurons, including several known weight control regions and several novel regions that might be functionally important for the BDNF-mediated regulation of energy homeostasis. Interestingly, several regions show very dense reciprocal connections with PVN BDNF neurons, including the lateral septum, the preoptic area, the ventromedial hypothalamic nucleus, the paraventricular thalamic nucleus, the zona incerta, the lateral parabrachial nucleus, the subiculum, the raphe magnus nucleus, and the raphe pallidus nucleus. These strong anatomical connections might be indicative of important functional connections. Therefore, we provide an outline of potential neural circuitry mediated by PVN BDNF neurons, which might be helpful to resolve the complex obesity network. |
| Databáze: | OpenAIRE |
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