Evaluation of Transcription Factor 7 like 2 polymorphisms and haplotypes in risk of Type 2 Diabetes
| Autor: | Ramin Saravani, Zahra Irani, Hamid Reza Galavi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetics endocrine system haplotype endocrine system diseases gene polymorphism business.industry tcf7l2 Haplotype nutritional and metabolic diseases 030209 endocrinology & metabolism Type 2 diabetes medicine.disease Transcription Factor 7-Like 2 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine Medicine hyperglycemia business TCF7L2 |
| Zdroj: | Romanian Journal of Laboratory Medicine, Vol 24, Iss 4, Pp 423-430 (2016) |
| ISSN: | 2284-5623 |
| Popis: | Type 2 diabetes (T2D) is a chronic disorder with different genetics and environmental factors. It is one of growing diseases in the world. Previous studies show association between Transcription Factor 7 Like2 (TCF7L2) and T2D. The current study set to evaluate the relation between TCF7L2 polymorphisms and T2D in Southeast Iran. The present case-control study was done on 250 T2D and 250 healthy controls (HCs). For genotyping polymorphisms TCF7L2 (rs11196205) and (rs4132670) Amplification-Refractory Mutation System-Polymers Chain Reaction (ARMS-PCR) was used. The results showed frequency rates of GC and CC genotypes increased in patients compared to controls (31% vs. 6% and 55% vs. 8%, respectively), showing a statistically significant difference (OR=2.67(1.37-5.21), P |
| Databáze: | OpenAIRE |
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