Novel Therapeutic Platform of Micelles and Nanogels from Dopa-Functionalized Triblock Copolymers
| Autor: | K.E.J. Olofsson, Eva Malmström Jonsson, Liguo Qin, Lisa Fortuin, Yanmiao Fan, Michael Malkoch, Yuning Zhang, Oliver C. J. Andrén, Carmen Cobo Sanchez |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Nanoparticle
Nanogels 02 engineering and technology 010402 general chemistry 01 natural sciences Micelle Polyethylene Glycols Biomaterials Drug Delivery Systems Amphiphile Copolymer General Materials Science Micelles Drug Carriers Aqueous solution Chemistry General Chemistry 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences Dihydroxyphenylalanine Drug delivery Click chemistry Nanomedicine Nanoparticles 0210 nano-technology Biotechnology |
| Zdroj: | Small (Weinheim an der Bergstrasse, Germany). 17(17) |
| ISSN: | 1613-6829 |
| Popis: | Multi-drug delivery systems constructed from a basic polymeric scaffold, and which have the ability to target a variety of biomedical applications, can streamline the development of nanomedicine to provide both environmental and economical relief. Herein, amphiphilic ABA-triblock copolymers are synthesized and assembled sequentially into micelles and nanogels as drug delivery systems following a thorough evaluation on advanced in vitro models to explore their potential for the treatment of cancer and bacterial infections. Short blocks of 5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one (MAC) are oligomerized from PEG6k and thereafter functionalized with dihydroxyphenylalanine (dopa)-functional thiols using thiol-ene coupling (TEC) click chemistry. The copolymers self-assemble into well-defined micelles in aqueous solution and are further formulated into nanogels via UV-induced TEC. The resulting spherical micelles and nanogels are stable nanoparticles, with sizes ranging between 100 and 200 nm. The nanogels are found to be non-toxic to a panel of cell lines and mask the toxicity of the potent drugs until their release. The nanogels would be superior to micelles for the elimination of cancer cells supported by both 2D cell culture and a 3D spheroid model. The opposite conclusion could be drawn for bacteria inhibition. |
| Databáze: | OpenAIRE |
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