Serum leptin concentrations in patients with short-bowel syndrome
| Autor: | José Manuel Gómez, Nuria Virgili, A. Molina, A.M. Pita, M. Farriol, Joan Soler |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Leptin Male Short Bowel Syndrome medicine.medical_specialty Malabsorption Adipose tissue Hyperphagia Critical Care and Intensive Care Medicine Body Mass Index chemistry.chemical_compound Sex Factors Internal medicine Electric Impedance Humans Medicine Triglycerides Aged Nutrition and Dietetics Anthropometry Nutritional Support business.industry Cholesterol digestive oral and skin physiology Age Factors Middle Aged Short bowel syndrome medicine.disease Endocrinology Parenteral nutrition Adipose Tissue chemistry Body Composition Regression Analysis Female business Bioelectrical impedance analysis Body mass index |
| Zdroj: | Clinical Nutrition. 19:333-338 |
| ISSN: | 0261-5614 |
| DOI: | 10.1054/clnu.2000.0110 |
| Popis: | Background : Short-bowel syndrome is a state of severe malabsorption resulting from absence or removal of the small bowel for several causes. A number of short-bowel patients develop hyperphagia. Leptin, a protein secreted from adipose tissue, signals the amount of energy stores to the brain. Objective : To study body composition and leptin regulation in short-bowel patients and to determine whether or not leptin concentrations are linked with hyperphagia. Design : We studied 25 short-bowel patients (remnant bowel less than 150 cm) and 31 controls and 10 oral nutrition. Fifteen patients received total parenteral nutrition and 10 oral nutrition. Anthropometric measurements, body composition (by bioelectrical impedance), and cholesterol, triacylglycerol and leptin concentrations were studied in all subjects. Results : There were no differences between short-bowel patients and controls in anthropometric variables, body composition, or leptin concentrations. Leptin concentrations were higher in short-bowel women than men (9.21±8.54 vs. 3.22±1.86 ng/ml, P =0.01). Leptin concentrations correlated positively with age (r=0.4, P =0.045), body mass index (r=0.52, P =0.007), fat mass (r=0.67, P =0.001) and body fat (r=0.68, P =0.0001); there were no correlations with other body composition parameters. We found no correlations between parenteral or oral nutrition and body composition parameters, or between leptin concentrations and the presence of hyperphagia. Logistic regression analysis showed that body fat correctly identified leptin concentrations in 60% of patients. Conclusions : Body composition, leptin concentrations and leptin regulation in patients with short-bowel syndrome are similar to those of controls. Leptin concentrations do not correlate with hyperphagia in short bowel-patients. |
| Databáze: | OpenAIRE |
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