Applicability of quantitative optical imaging techniques for intraoperative perfusion diagnostics
| Autor: | Iwan Dobbe, E. Heeg, Ton G. van Leeuwen, Sanne M. Jansen, Dan M.J. Milstein, Daniel M. de Bruin, Simon D. Strackee, Dirk J. Faber |
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| Přispěvatelé: | Maxillofacial Surgery (AMC), MKA AMC (OII, ACTA), APH - Personalized Medicine, APH - Quality of Care, Graduate School, Biomedical Engineering and Physics, Urology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Cardiovascular Sciences, Oral and Maxillofacial Surgery, Other Research, Plastic, Reconstructive and Hand Surgery, ACS - Diabetes & metabolism, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Materials science
genetic structures Perfusion Imaging Biomedical Engineering Hemodynamics 01 natural sciences Imaging phantom 010309 optics Biomaterials 03 medical and health sciences Speckle pattern 0302 clinical medicine Optics SDG 3 - Good Health and Well-being Optical coherence tomography 0103 physical sciences Microscopy medicine Humans medicine.diagnostic_test business.industry Optical Imaging Blood flow eye diseases Atomic and Molecular Physics and Optics Diffuse optical imaging Electronic Optical and Magnetic Materials Regional Blood Flow 030220 oncology & carcinogenesis sense organs business Perfusion Blood Flow Velocity Tomography Optical Coherence Biomedical engineering |
| Zdroj: | Journal of biomedical optics, 22(8):086004. SPIE Jansen, S M, de Bruin, D M, Faber, D J, Dobbe, I J G G, Heeg, E, Milstein, D M J, Strackee, S D & van Leeuwen, T G 2017, ' Applicability of quantitative optical imaging techniques for intraoperative perfusion diagnostics : A comparison of laser speckle contrast imaging, sidestream dark-field microscopy, and optical coherence tomography ', Journal of biomedical optics, vol. 22, no. 8, 086004 . https://doi.org/10.1117/1.JBO.22.8.086004 Journal of Biomedical Optics, 22(8):086004. SPIE Journal of biomedical optics, 22(8), 086004-9. SPIE |
| ISSN: | 1560-2281 1083-3668 |
| Popis: | Patient morbidity and mortality due to hemodynamic complications are a major problem in surgery. Optical techniques can image blood flow in real-time and high-resolution, thereby enabling perfusion monitoring intraoperatively. We tested the feasibility and validity of laser speckle contrast imaging (LSCI), optical coherence tomography (OCT), and sidestream dark-field microscopy (SDF) for perfusion diagnostics in a phantom model using whole blood. Microvessels with diameters of 50, 100, and 400 mu m were constructed in a scattering phantom. Perfusion was simulated by pumping heparinized human whole blood at five velocities (0 to 20 mm/s). Vessel diameter and blood flow velocity were assessed with LSCI, OCT, and SDF. Quantification of vessel diameter was feasible with OCT and SDF. LSCI could only visualize the 400-mu m vessel, perfusion units scaled nonlinearly with blood velocity. OCT could assess blood flow velocity in terms of inverse OCT speckle decorrelation time. SDF was not feasible to measure blood flow; however, for diluted blood the measurements were linear with the input velocity up to 1 mm/s. LSCI, OCT, and SDF were feasible to visualize blood flow. Validated blood flow velocity measurements intraoperatively in the desired parameter (mL.min(-1).g(-1)) remain challenging. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) |
| Databáze: | OpenAIRE |
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