Respiratory variation in aortic blood peak velocity and caudal vena cava diameter can predict fluid responsiveness in anaesthetised and mechanically ventilated dogs
| Autor: | Paolo Franci, Massimo Bucci, R. Rabozzi, Carlo Guglielmini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Vena Cava medicine.medical_treatment Fluid responsiveness Blood Pressure 0403 veterinary science Anaesthesia 0302 clinical medicine Mechanical ventilation 030202 anesthesiology Dog General anaesthesia Anesthesia Prospective Studies Respiratory system Preload indices Aorta Respiration 04 agricultural and veterinary sciences medicine.anatomical_structure Predictive value of tests Anesthesia General Animals Blood Flow Velocity Coronary Circulation Dogs Female Predictive Value of Tests Regional Blood Flow Respiration Artificial Vena Cava Inferior Animal Science and Zoology Veterinary (all) Artificial Inferior 040301 veterinary sciences 03 medical and health sciences Coronary circulation medicine.artery medicine General General Veterinary business.industry Blood pressure business |
| Popis: | Dynamic preload indices, such as systolic pressure variation (SPV), aortic flow peak velocity variation (ΔVpeak) and distensibility index of the caudal vena cava (CVCDI), are reliable indices for predicting fluid responsiveness in humans. This study aimed to investigate the ability of these indices to predict fluid response in 24 healthy dogs undergoing general anaesthesia and mechanical ventilation. Aortic flow peak velocity variation (∆Vpeak), CVCDI, and SPV were calculated before volume expansion (5mL/kg bolus of lactated Ringer's solution). The aortic velocity time integral (VTI) was measured before and after volume expansion as a surrogate of stroke volume. Dogs were considered responders (n=9) when the VTI increase was ≥15% and non-responders (n=15) when the increase was15%.Before volume expansion, ΔVpeak, CVCDI and SPV were higher in responders than in non-responders (P=0.0009, P=0.0003, and P=0.0271, respectively). Receiver operating characteristic (ROC) curves were plotted for the three indices. The areas under the ROC curves for SPV, ΔVpeak, and CVCDI were 0.91 (CI 0.73-0.99; P=0.0001), 0.95 (CI 0.77-1; P=0.0001), and 0.78 (CI 0.56-0.92; P=0.015), respectively. The best cut-offs were 6.7% for SPV (sensitivity, 77.78%; specificity, 93.33%), 9.4% for ΔVpeak (sensitivity, 88.89%; specificity, 100%), and 24% for CVCDI (sensitivity, 77.78%; specificity, 73.33). In conclusion, ΔVpeak, CVCDI, and SPV are reliable predictors of fluid responsiveness in healthy dogs undergoing general anaesthesia and mechanical ventilation. |
| Databáze: | OpenAIRE |
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