Thirty-Three Long-Term Survivors After Cytoreductive Surgery in Patients With Peritoneal Metastases From Colorectal Cancer: A Retrospective Descriptive Study
| Autor: | Yutaka Yonemura, Shinya Yoshida, Akiyoshi Mizumoto, Naveen Padmanabhan, Masumi Ichinose, Haruaki Ishibashi, Shouzou Sako, Koya Hida, Yasuyuki Kamada |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Colorectal cancer lcsh:Surgery Gastroenterology lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Surgical oncology Internal medicine Signet ring cell carcinoma Medicine Humans Cytoreductive surgery Survivors Peritoneal Neoplasms Retrospective Studies HIPEC business.industry Research Long-term survivors lcsh:RD1-811 Cytoreduction Surgical Procedures Hyperthermia Induced medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prognosis Combined Modality Therapy Survival Rate Oncology 030220 oncology & carcinogenesis Conventional PCI Peritoneal metastasis Peritoneal Cancer Index Adenocarcinoma 030211 gastroenterology & hepatology Surgery Histopathology Hyperthermic intraperitoneal chemotherapy business Colorectal Neoplasms |
| Zdroj: | World Journal of Surgical Oncology World Journal of Surgical Oncology, Vol 19, Iss 1, Pp 1-13 (2021) |
| Popis: | BackgroundCytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival in selected patients with peritoneal metastasis (PM) from colorectal cancer (CRC). However, little has been reported on characteristics and clinical course of long-term survivors with CRC-PM beyond 5 years. The objective of this study was to identify the clinical and oncological features affecting long-term survival of CRC-PM after comprehensive treatment.MethodsBetween January 1990 and April 2015, CRC-PM patients who underwent CRS with or without HIPEC in two Japanese tertiary hospitals were analyzed. Clinicopathological parameters and therapeutic details for long-term survivors (patients surviving ≥ 5 years after CRS) were described and compared with those for non-survivors (patients surviving ResultsThe study identified 236 patients with CRC-PM who underwent CRS, with a median follow-up period of 2.5 years. Thirty-three patients (14.0%) were considered as long-term survivors. Compared with non-survivors, long-term survivors had a lower median peritoneal cancer index (PCI) [4 (1–27) vs 9 (0–39),ppp= 0.018]. Regarding histopathology, long-term survivors more frequently had mucinous adenocarcinoma than non-survivors [8/33 (24.2%) vs 27/203 (13.3%)] and less likely exhibited poorly differentiated or signet ring cell carcinoma [2/33 (6.1%) vs 48/203 (23.7%)] (pConclusionsOne in seven patients with CRC-PM achieved the long-term milestone after CRS. A long-term survival was associated with the presence of low PCI, CCR-0, metachronous onset, and mucinous histology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|