A clinical evaluation of the Janus Web Application, a software screening tool for drug-drug interactions
| Autor: | Buster Mannheimer, Christer von Bahr, Sara Eklöf, Johanna Ulfvarson, Monica Bergqvist |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Drug medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions media_common.quotation_subject Context (language use) Pharmacology Medical Records law.invention Drug Utilization Review law Surveys and Questionnaires medicine Humans Web application Drug Interactions Pharmacology (medical) Screening tool Intensive care medicine Aged media_common Sweden Clinical pharmacology business.industry Medical record General Medicine Decision Support Systems Clinical medicine.disease Pharmaceutical Preparations Female business Clinical evaluation Software Adverse drug reaction |
| Zdroj: | European Journal of Clinical Pharmacology. 64:1209-1214 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/s00228-008-0547-x |
| Popis: | To evaluate the clinical relevance of the Janus Web Application (JWA) in screening for potential drug-drug interactions (DDIs). One hundred and fifty patients taking two drugs or more were studied. Potential DDIs were identified by the JWA. Interviewing the patient and looking into his/her medical records provided complementing information. A clinical pharmacologist judged which potential DDIs were clinically relevant. Potentially relevant DDIs identified by the JWA were then correlated with clinically relevant DDIs. A total of 150 significant potential DDIs were found. Sixteen percent (24/150) were judged to be clinically relevant. A very small proportion of DDIs was considered clinically relevant in the specific clinical context. To optimise the software’s user-friendliness, the following points need to be considered: the possibility of eliminating trivial potential DDIs, individualising drug alerts, and providing written information, accessible via a hyperlink. |
| Databáze: | OpenAIRE |
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