Evaluation of Intestinal Function in Children With Autism and Gastrointestinal Symptoms
| Autor: | David S. Newburg, Rafail I. Kushak, Eirini Nestoridi, Katherine F. Murray, Timothy Buie, Harland S. Winter, Ceng Chen |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Duodenum Biopsy Child Health Services Enzyme-Linked Immunosorbent Assay behavioral disciplines and activities Child health services Gastroenterology 03 medical and health sciences 0302 clinical medicine Intestinal mucosa Intestinal inflammation Internal medicine mental disorders medicine Gut permeability Humans Autistic Disorder Intestinal Mucosa Child Duodenoscopy business.industry Case-control study Inflammatory Bowel Diseases medicine.disease Disaccharidase Lactoferrin Case-Control Studies Pediatrics Perinatology and Child Health Autism 030211 gastroenterology & hepatology Female business Leukocyte L1 Antigen Complex 030217 neurology & neurosurgery |
| Zdroj: | Journal of pediatric gastroenterology and nutrition. 62(5) |
| ISSN: | 1536-4801 |
| Popis: | Alterations in intestinal function, often characterized as a "leaky gut," have been attributed to children who are on the autism spectrum. Disaccharidase activity, intestinal inflammation, and permeability were analyzed in 61 children with autism and 50 nonautistic individuals with gastrointestinal symptoms.All patients had duodenal biopsies assayed for lactase, sucrase, maltase, and palatinase activity. Intestinal permeability was evaluated by rhamnose/lactulose test and measured by high-performance liquid chromatography-mass spectrometry. Intestinal inflammation was evaluated by fecal calprotectin and lactoferrin levels using enzyme-linked immunosorbent assay and histology.Some children with autism had mild levels of mucosal inflammation on intestinal biopsy. Disaccharidase activity was not different in autistic and nonautistic individuals. Fecal calprotectin and lactoferrin were similar in both groups. Differences between lactulose and rhamnose recovery and lactulose/rhamnose ratio in urine were not statistically different in patients with and without autism.The present study supports the observation that children with autism who have symptoms of gastrointestinal disorders have objective findings similar to children without autism. Neither noninvasive testing nor endoscopic findings identify gastrointestinal pathology specific to autism, but may be of benefit in identifying children with autism who have atypical symptoms. |
| Databáze: | OpenAIRE |
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