Thyroid Evaluation in Patients with Primary Hyperparathyroidism
| Autor: | Syoji Kuroki, Hiroto Yamashita, Yutaka Koga, Shiro Noguchi, Shin Watanabe, Masao Tanaka, Shinya Uchino, Hiroyuki Yamashita, Toshihiro Masatsugu, Ryuichi Nishii, Akira Ohshima |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adenoma
Adult Male Thyroid nodules Thyroiditis endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Malignancy Sensitivity and Specificity Phosphates Endocrinology Biopsy medicine Carcinoma Humans Thyroid Neoplasms Thyroid Nodule Aged Ultrasonography Aged 80 and over medicine.diagnostic_test Goiter business.industry Hyperparathyroidism Thyroid disease Biopsy Needle Thyroid Middle Aged medicine.disease Thyroid Diseases Carcinoma Papillary Graves Disease medicine.anatomical_structure Parathyroid Hormone Concomitant Calcium Female Radiology business Primary hyperparathyroidism |
| Zdroj: | Endocrine Journal. 52:177-182 |
| ISSN: | 1348-4540 0918-8959 |
| DOI: | 10.1507/endocrj.52.177 |
| Popis: | We evaluated the efficacy of preoperative high-resolution ultrasonography (US) for diagnosing possible concomitant thyroid disease which affects the surgical management in patients with primary hyperparathyroidism (pHPT). One hundred and nine patients with sporadic pHPT underwent US with or without ultrasound-guided fine-needle aspiration biopsy (US-FNAB). Diagnosis of concomitant thyroid nodules by US and US-FNAB were compared with the histopathological findings. Of the 109 patients, 19 (17.4%) had malignant thyroid nodules, 26 (23.9%) had benign thyroid nodules alone, and 12 (11.0%) had diffuse goiter. The sensitivity, specificity, and accuracy of diagnosing 72 thyroid nodules were 91.3%, 91.8%, and 91.7% for US, 57.9%, 94.3%, and 81.5% for US-FNAB, and 95.7%, 91.8%, and 93.1% for combined US and US-FNAB, respectively. True positive/false negative ratio of US-FNAB diagnosis was significantly lower in nodules of 5-9 mm than nodules of 10 mm or more. Four unexpected thyroid cancers existed at a different site in 3 of the 39 patients with palpable thyroid disease. Five thyroid cancers were histopathologically confirmed in 5 (7.1%) of 70 patients without palpable thyroid disease. Eight (88.9%) of the 9 non-palpable thyroid cancers were accurately diagnosed by combined US and US-FNAB. Preoperative US is useful for evaluation of possible concomitant thyroid disease, especially for prediction of malignancy. |
| Databáze: | OpenAIRE |
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