Expression of Intermediate Filament Proteins in the Adult Human Cochlea
| Autor: | Egbert H. Huizing, J. E. Veldman, Henk Bouman, Louis J. J. M. Bauwens, Frans C. S. Ramaekers |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Neurofilament Intermediate Filaments Vimentin macromolecular substances Desmin 03 medical and health sciences Cytokeratin 0302 clinical medicine Reference Values Glial Fibrillary Acidic Protein Hair Cells Auditory otorhinolaryngologic diseases medicine Humans 030223 otorhinolaryngology Intermediate filament Organ of Corti Cochlea Aged biology Glial fibrillary acidic protein General Medicine Cochlear Duct Middle Aged Immunohistochemistry medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis biology.protein Keratins sense organs |
| Zdroj: | Annals of Otology, Rhinology & Laryngology. 100:211-218 |
| ISSN: | 1943-572X 0003-4894 |
| DOI: | 10.1177/000348949110000309 |
| Popis: | The immunohistochemical localization of intermediate filament proteins was studied in frozen sections of chemically fixed, nondecalcified adult human cochleas. Cytokeratins were found in all epithelial cells lining the cochlear duct (including most supporting cells of the organ of Corti) but were absent in the hair cells. Neurofilament proteins were present in the nerve endings at the hair cells, in the neural bundles, and in the ganglion cells. Vimentin staining occurred in most of the supporting structures and was roughly complementary to the regions showing cytokeratin staining and neurofilament staining. However, the region of the spiral prominence and outer sulcus, as well as the pillar cells and Deiters' cells in the organ of Corti, showed coexpression of vimentin and cytokeratins. No definite immunostaining was observed with antibodies to desmin and glial fibrillary acidic protein. |
| Databáze: | OpenAIRE |
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