Study of the possible link of 25-hydroxyvitamin D with Epstein-Barr virus and human herpesvirus 6 in patients with multiple sclerosis
| Autor: | C. López de Silanes, Isabel Ortega-Madueño, R. Arroyo, Maria Josefa Torrejon, Roberto Alvarez-Lafuente, Maria Inmaculada Dominguez-Mozo, José M. García-Domínguez, Ignacio Casanova, M L Martínez-Ginés, Silvia Pérez-Pérez, María Ángel García-Martínez, Yolanda Aladro, L. López-Lozano |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Herpesvirus 4 Human Multiple Sclerosis Herpesvirus 6 Human medicine.disease_cause Virus Young Adult 03 medical and health sciences 0302 clinical medicine Genotype medicine Vitamin D and neurology Humans Vitamin D Calcifediol biology business.industry Multiple sclerosis Herpesviridae Infections Viral Load biology.organism_classification medicine.disease Epstein–Barr virus 030104 developmental biology Neurology Immunology biology.protein Female Human herpesvirus 6 Neurology (clinical) Antibody business Viral load 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Neurology. 25:1446-1453 |
| ISSN: | 1351-5101 |
| Popis: | Background and purpose Although the causes of multiple sclerosis (MS) remain partially unknown, environmental and genetic factors are thought to play a role in its aetiopathogenesis. Hypovitaminosis D, Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6) infections have been described as possible MS triggers. Our aim was to analyse the possible link between 25-hydroxyvitamin D [25(OH)D] and viruses in patients with MS. Methods We included 482 patients with MS in a 2-year study. Serum samples were collected to analyse 25(OH)D levels and, according to sample availability, antibody titres against EBV and HHV-6 by enzyme-linked immunosorbent assay. DNA was extracted from blood in order to analyse EBV and HHV-6 viral load by quantitative real-time polymerase chain reaction and to genotype MS-related single nucleotide polymorphisms (rs3135388, rs2248359 and rs12368653) when possible. Results The 25(OH)D levels were significantly higher in the first semester of the year than in the second. Carriers of the risk allele rs2248359-C showed lower 25(OH)D levels than non-carriers. For EBV, viral load was significantly higher when 25(OH)D levels were low, demonstrating an inverse correlation between 25(OH)D levels and EBV load. Conclusions The 25(OH)D levels could be involved in the regulation of EBV replication/reactivation in patients with MS. |
| Databáze: | OpenAIRE |
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