Infectious Esophagitis in Romanian Children: From Etiology and Risk Factors to Clinical Characteristics and Endoscopic Features
| Autor: | Ciprian Silaghi, Madalina Adriana Bordea, L.S. Pepelea, Lia Monica Junie, Dan Gheban, Gabriel Samașca, Iulia Lupan, Alexandru Pîrvan, Carmen Costache |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
esophagitis etiology prevalence lcsh:Medicine Disease Article endoscopic assessment 03 medical and health sciences 0302 clinical medicine Internal medicine medicine risk factors Risk factor clinical characteristics Immunodeficiency business.industry lcsh:R Heartburn General Medicine medicine.disease Dysphagia 030220 oncology & carcinogenesis Cohort Etiology 030211 gastroenterology & hepatology medicine.symptom business Esophagitis |
| Zdroj: | Journal of Clinical Medicine, Vol 9, Iss 939, p 939 (2020) Journal of Clinical Medicine Volume 9 Issue 4 |
| ISSN: | 2077-0383 |
| Popis: | Objectives. The aim of this study is to provide information about prevalence, etiology, risk factors, clinical characteristics and endoscopic features of various types of infectious esophagitis in children. Methods. We performed a total of 520 upper gastrointestinal tract endoscopies in Pediatric Clinic II, Emergency Hospital for Children, Cluj-Napoca. Indications for endoscopy in our cohort were gastrointestinal tract symptoms such as dysphagia, heartburn, or appetite loss. Results. The prevalence of infectious esophagitis in the study population was 2.11% (11 patients). Candida albicans (C. albicans) was the most frequent cause. Our data illustrates that herpes simplex virus (HSV)-induced esophagitis is common in immunocompromised patients and should be systematically suspected in cases of severe dysphagia, heartburn, or hematemesis. In the present study, all cytomegalovirus (CMV) esophagitis patients were immunocompromised. Immunodeficiency (81.8%) and prolonged antibiotic therapy with broad-spectrum antibiotics were by far the most important risk factors involved in the pathogenicity of the disease. Dysphagia, appetite loss, heartburn, epigastralgia, and hematemesis were the main clinical manifestations. Infectious esophagitis was associated with significant mortality. In four patients, endoscopy during life showed signs of infectious esophagitis however, the precise etiology was only established post-mortem, in the pathological anatomy laboratory department. A risk factor involved in pathogenesis of post-mortem diagnosed infectious esophagitis is the DiGeorge syndrome for CMV and HSV patients. Conclusions. The study illustrates that infectious esophagitis should be considered in immunocompromised infants with prolonged antibiotic therapy with broad-spectrum antibiotics. |
| Databáze: | OpenAIRE |
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