Anti-Inflammatory Activity of Diterpene Alkaloids from Aconitum baikalense
| Autor: | Yu. V. Nesterova, G. N. Zyuz’kov, S. V. Pushkarskii, A. V. Krapivin, S. G. Aksinenko, T. N. Povetieva, N. I. Suslov |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.drug_class
Carrageenan induced inflammation Anti-Inflammatory Agents Drug Evaluation Preclinical General Biochemistry Genetics and Molecular Biology Anti-inflammatory chemistry.chemical_compound Animals Outbred Strains medicine Animals Edema heterocyclic compounds Aconitum Nonsteroidal biology Traditional medicine Plant Extracts General Medicine Diclofenac Sodium biology.organism_classification Hindlimb Biochemistry chemistry Mice Inbred CBA Diterpenes Diterpene |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 156:665-668 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-014-2421-4 |
| Popis: | We compared anti-inflammatory activity of individual diterpene alkaloids isolated from Aconitum baikalense (napelline, songorine, hypaconitine, mesaconitine, 12-epinapelline N-oxide) under conditions of acute inflammation of different genesis. The tested substances showed high antiexudative activity comparable with that of sodium diclofenac. Unlike nonsteroidal anti-inflammatory drugs, diterpene alkaloids exerted no ulcerogenic effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink