Serum anti-Müllerian hormone concentration in women with polycystic ovary syndrome and type 1 diabetes mellitus

Autor: Maria Gorska, Monika Karczewska-Kupczewska, Slawomir Wolczynski, Robert Milewski, Irina Kowalska, Agnieszka Łebkowska, Agnieszka Adamska, Elzbieta Otziomek, Agnieszka Nikolajuk
Rok vydání: 2016
Předmět:
Adult
Anti-Mullerian Hormone
endocrine system
medicine.medical_specialty
Outpatient Clinics
Hospital
endocrine system diseases
Endocrinology
Diabetes and Metabolism
030209 endocrinology & metabolism
Ovary
Sensitivity and Specificity
Hospitals
University
Young Adult
03 medical and health sciences
Follicle-stimulating hormone
0302 clinical medicine
Endocrinology
Sex hormone-binding globulin
Waist–hip ratio
Ovarian Follicle
immune system diseases
Internal medicine
Humans
Medicine
Retrospective Studies
030219 obstetrics & reproductive medicine
biology
business.industry
Free androgen index
Reproducibility of Results
nutritional and metabolic diseases
Anti-Müllerian hormone
Organ Size
Luteinizing Hormone
Polycystic ovary
female genital diseases and pregnancy complications
Up-Regulation
Radiography
Cross-Sectional Studies
Diabetes Mellitus
Type 1
medicine.anatomical_structure
biology.protein
Female
Poland
business
Body mass index
Biomarkers
Polycystic Ovary Syndrome
Zdroj: Metabolism. 65:804-811
ISSN: 0026-0495
DOI: 10.1016/j.metabol.2016.02.005
Popis: A single prior study conducted in Chilean women has shown that women with type 1 diabetes mellitus (T1DM) and polycystic ovary syndrome (PCOS) have a normal serum anti-Müllerian hormone (AMH) concentrations despite polycystic ovarian morphology. As it is not clear why women with PCOS+T1DM would not have an elevated concentrations of AMH, we hypothesize that women with T1DM and PCOS have a similar hormonal profile and serum AMH levels as is observed in classic PCOS.We studied 89 women: 37 with T1DM (16 with PCOS+T1DM, 21 with T1DM/no-PCOS), 36 with PCOS (PCOS) and 16 healthy women (control group) matched for age and body mass index (BMI). A clinical examination, determination of serum AMH and sex hormones, and an ultrasonographic evaluation of the ovaries were performed for all study participants.Serum AMH concentrations were significantly higher in women with PCOS+T1DM than in those with T1DM/no-PCOS (p0.001) and was not different between both PCOS groups (PCOS vs PCOS+T1DM). Ovarian volume and ovarian follicle count did not differ between women with PCOS+T1DM and PCOS. The number of ovarian follicles was higher in patients with PCOS+T1DM and PCOS versus the control (p=0.007, p0.001) and versus cases of T1DM/no-PCOS (p0.001, p0.001, respectively). Cross-sectionally, AMH concentrations correlated positively with luteinizing hormone (LH) (r=0.4; p0.001), testosterone (r=0.2, p=0.02), ovarian volume (r=0.4, p0.001) and follicle count (r=0.7, p0.001). In both groups, PCOS+T1DM and PCOS, AMH was related to LH (r=0.5; p=0.036; r=0.3; p=0.031) and to ovarian follicle number (r=0.7; p0.001; r=0.4; p=0.006). In multivariate logistic regression analysis, serum AMH was the only predictor of PCOS in T1DM women (OR=1.73; 95% CI 1.07-2.79, p=0.023).Women with T1DM and PCOS have a similar hormonal profile and serum AMH concentrations as observed in classic PCOS.
Databáze: OpenAIRE
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