Magnetic resonance elastography biomarkers for detection of histologic alterations in nonalcoholic fatty liver disease in the absence of fibrosis
| Autor: | Claude B. Sirlin, Meng Yin, Kang Wang, Michael S. Middleton, Scott B. Reeder, Jonathan Hooker, Ethan Z. Sy, Kathryn J. Fowler, Adrija Mamidipalli, Jeffrey B. Schwimmer, Bin Song, Jun Chen, Yingzhen N. Zhang, Kevin J. Glaser, Rohit Loomba, Yali Qu, Tanya Wolfson, Richard L. Ehman, Yesenia Covarrubias, Mark A. Valasek, Anthony Gamst |
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| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Age adjustment Chronic Liver Disease and Cirrhosis Clinical Sciences Inflammation Gastroenterology Article Oral and gastrointestinal 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Elasticity imaging techniques Fibrosis Non-alcoholic Fatty Liver Disease Clinical Research Internal medicine Nonalcoholic fatty liver disease medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Retrospective Studies Univariate analysis screening and diagnosis medicine.diagnostic_test business.industry Liver Disease Magnetic resonance imaging General Medicine medicine.disease Magnetic Resonance Imaging Magnetic resonance elastography 4.1 Discovery and preclinical testing of markers and technologies Detection Nuclear Medicine & Medical Imaging Liver 030220 oncology & carcinogenesis Liver biopsy Elasticity Imaging Techniques Biomedical Imaging Radiology medicine.symptom business Digestive Diseases Biomarkers |
| Zdroj: | European radiology, vol 31, iss 11 Eur Radiol |
| Popis: | To investigate associations between histology and hepatic mechanical properties measured using multiparametric magnetic resonance elastography (MRE) in adults with known or suspected nonalcoholic fatty liver disease (NAFLD) without histologic fibrosis. This was a retrospective analysis of 88 adults who underwent 3T MR exams including hepatic MRE and MR imaging to estimate proton density fat fraction (MRI-PDFF) within 180 days of liver biopsy. Associations between MRE mechanical properties (mean shear stiffness (|G*|) by 2D and 3D MRE, and storage modulus (G′), loss modulus (G″), wave attenuation (α), and damping ratio (ζ) by 3D MRE) and histologic, demographic and anthropometric data were assessed. In univariate analyses, patients with lobular inflammation grade ≥ 2 had higher 2D |G*| and 3D G″ than those with grade ≤ 1 (p = 0.04). |G*| (both 2D and 3D), G′, and G″ increased with age (rho = 0.25 to 0.31; p ≤ 0.03). In multivariable regression analyses, the association between inflammation grade ≥ 2 remained significant for 2D |G*| (p = 0.01) but not for 3D G″ (p = 0.06); age, sex, or BMI did not affect the MRE-inflammation relationship (p > 0.20). 2D |G*| and 3D G″ were weakly associated with moderate or severe lobular inflammation in patients with known or suspected NAFLD without fibrosis. With further validation and refinement, these properties might become useful biomarkers of inflammation. Age adjustment may help MRE interpretation, at least in patients with early-stage disease. • Moderate to severe lobular inflammation was associated with hepatic elevated shear stiffness and elevated loss modulus (p =0.04) in patients with known or suspected NAFLD without liver fibrosis; this suggests that with further technical refinement these MRE-assessed mechanical properties may permit detection of inflammation before the onset of fibrosis in NAFLD. • Increasing age is associated with higher hepatic shear stiffness, and storage and loss moduli (rho = 0.25 to 0.31; p ≤ 0.03); this suggests that age adjustment may help interpret MRE results, at least in patients with early-stage NAFLD. |
| Databáze: | OpenAIRE |
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