Safety and effectiveness of an acellular pertussis vaccine in subjects with Down's syndrome
| Autor: | S. Anfuso, Teresa Mattina, S. Li Volti, A. Ursino, Sebastiano Bianca, Florindo Mollica, L Mauro |
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| Rok vydání: | 1996 |
| Předmět: |
Bordetella pertussis
Down syndrome Whooping Cough medicine Humans Whooping cough Pertussis Vaccine Reactogenicity biology business.industry Immunogenicity Infant General Medicine medicine.disease biology.organism_classification Treatment Outcome Immunization Child Preschool Immunoglobulin G Pediatrics Perinatology and Child Health Immunology Antibody Formation biology.protein Neurology (clinical) Antibody Down Syndrome Safety Trisomy business |
| Zdroj: | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 12(2) |
| ISSN: | 0256-7040 |
| Popis: | We evaluated the reactogenicity and immunogenicity of an acellular pertussis vaccine in 24 subjects affected by Down's syndrome and in 10 normal infants. Neither general nor local adverse reactions were observed in either group of subjects. The new acellular vaccine administration elicited protective levels of antibodies in all the subjects with Down's syndrome, although the geometric mean titres of IgG antibodies against Bordetella pertussis in these subjects were significantly lower than in normal controls. |
| Databáze: | OpenAIRE |
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