The SRC Family Protein Tyrosine Kinase p62 yes Controls Polymeric IgA Transcytosis In Vivo
| Autor: | Marius Sudol, Frédéric Luton, Keith E. Mostov, Jean-Pierre Vaerman, Marcel Verges |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Immunoglobulin A Asialoglycoproteins Plasma protein binding Receptor tyrosine kinase Oncogene Protein pp60(v-src) Rats Sprague-Dawley Mice Proto-Oncogene Proteins Animals Fetuins Molecular Biology Mice Knockout Proto-Oncogene Proteins c-yes biology Receptors Polymeric Immunoglobulin Biological Transport Cell Biology Precipitin Tests Molecular biology Rats Cell biology src-Family Kinases Liver Transcytosis biology.protein alpha-Fetoproteins Signal transduction Polymeric immunoglobulin receptor Tyrosine kinase Protein Binding Signal Transduction |
| Zdroj: | Molecular Cell. 4(4):627-632 |
| ISSN: | 1097-2765 |
| DOI: | 10.1016/s1097-2765(00)80213-0 |
| Popis: | Transcytosis of polymeric immunoglobulin A (pIgA) across epithelial cells is mediated by the polymeric immunoglobulin receptor (pIgR). Binding of pIgA to pIgR stimulates transcytosis of the pIgA-pIgR complex via a signal transduction pathway that is dependent on a protein tyrosine kinase (PTK) of the SRC family. Here we identify the PTK as p62(yes). We demonstrate the specific physical and functional association of the pIgR with p62(yes) in rodent liver. Analysis of p62(yes) knockout mice revealed a dramatic reduction in the association of tyrosine kinase activity with the pIgR and in transcytosis of pIgA. We conclude that p62(yes) controls pIgA transcytosis in vivo. |
| Databáze: | OpenAIRE |
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