Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells
| Autor: | Kouichi Sugaya, Naoki Abe, Aika Takahashi, Jun-ichi Onose, Takehito Terajima |
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| Rok vydání: | 2018 |
| Předmět: |
Bridged-Ring Compounds
Clinical Biochemistry Pharmaceutical Science medicine.disease_cause Inhibitory postsynaptic potential 01 natural sciences Biochemistry Cell Degranulation LYN Cell Line Tumor Drug Discovery Anti-Allergic Agents medicine Animals Secretion Mast Cells Molecular Biology Protein Kinase Inhibitors 010405 organic chemistry Chemistry Receptors IgE Tumor Necrosis Factor-alpha Organic Chemistry Interleukin Molecular biology beta-N-Acetylhexosaminidases 0104 chemical sciences Rats 010404 medicinal & biomolecular chemistry Bisorbicillinol src-Family Kinases Allergic response Molecular Medicine Tumor necrosis factor alpha Tyrosine kinase Signal Transduction |
| Zdroj: | Bioorganicmedicinal chemistry letters. 29(6) |
| ISSN: | 1464-3405 |
| Popis: | Bisorbicillinol, which is isolated from Trichoderma sp. USF2690, is an inhibitor of β-hexosaminidase release and tumor necrosis factor (TNF)-α, and Interleukin (IL)-4 secretion from rat basophilic leukemia (RBL-2H3) cells, with IC50 values of 2.8 μM, 2.9 μM and 2.8 μM respectively. We showed that the inhibitory mechanism of β-hexosaminidase release and TNF-α secretion involved inhibition of Lyn, a tyrosine kinase. The inhibitory activities of bisorbicillinol indicate that this compound is a new candidate anti-allergic agent. |
| Databáze: | OpenAIRE |
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