Efficacy of rifaximin, a poorly absorbed rifamycin antimicrobial agent, for hepatic encephalopathy in Japanese patients
| Autor: | Koichi Tokushige, Atsuko Kakihara, Seiichi Mawatari, Shigeho Maenohara, Takuya Hiwaki, Yasushi Imamura, Shuji Kanmura, Akio Ido, Hirofumi Uto, Akiko Saishoji, Yasunari Hiramine |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cirrhosis Hepatology business.industry Hazard ratio Encephalopathy Therapeutic effect Rifamycin medicine.disease Gastroenterology Rifaximin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Infectious Diseases chemistry 030220 oncology & carcinogenesis Internal medicine medicine 030211 gastroenterology & hepatology Cumulative incidence business Hepatic encephalopathy |
| Zdroj: | Hepatology research : the official journal of the Japan Society of HepatologyREFERENCES. 51(4) |
| ISSN: | 1386-6346 |
| Popis: | AIM Rifaximin is recommended as treatment for hepatic encephalopathy (HE) that targets intestinal bacterial flora. Although combined use with synthetic disaccharides is the standard of care worldwide, the therapeutic effects of rifaximin for overt encephalopathy (OHE) in Japanese patients have not been examined sufficiently. We examined the therapeutic effects of rifaximin for OHE in Japanese patients. METHODS A total of 76 patients who developed OHE of West Haven grade II or higher at least once within the 12 months before starting rifaximin were included. Blood ammonia levels and the incidence of OHE during the 12 months before and after starting rifaximin therapy were compared in a before-and-after study. Rifaximin efficacy and predictors of efficacy were also examined. RESULTS Post-treatment blood ammonia levels were significantly lower than pretreatment levels. The mean annual number of OHE incidents and intravenous branched-chain amino acid preparations used per patient were significantly lower after starting rifaximin therapy (2.51 vs. 0.76 times/year, p |
| Databáze: | OpenAIRE |
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