Heterogeneity of c-Met expression in Chinese gastric cancer patients
| Autor: | Jia Xu, Maoran Li, Chunchao Zhu, Hui Cao, Gang Zhao |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male C-Met Patient subgroups Kaplan-Meier Estimate Biology Pathology and Forensic Medicine chemistry.chemical_compound Asian People Stomach Neoplasms Biomarkers Tumor medicine Humans In Situ Hybridization Fluorescence Aged Aged 80 and over Polysomy medicine.diagnostic_test Middle Aged Proto-Oncogene Proteins c-met medicine.disease Immunohistochemistry Molecular biology chemistry Homogeneous Cancer research Female Fluorescence in situ hybridization |
| Zdroj: | Human Pathology. 46:1901-1907 |
| ISSN: | 0046-8177 |
| DOI: | 10.1016/j.humpath.2015.06.025 |
| Popis: | c-Met is an attractive target for gastric cancer (GC) therapy, and detection of c-Met expression is critical for diagnosis. The aims of this study were to quantify the heterogeneous expression of c-Met in GC and to explore its impact on diagnosis. The expression of c-Met in 199 tumor fragments derived from 47 GC patients was evaluated by immunohistochemistry. In parallel, copy numbers of MET were determined by fluorescence in situ hybridization. Expression of c-Met was observed in 22 patients, and 18 (81.8%) of 22 were heterogeneous; but the incidence rate of heterogeneity was not significantly different among patient subgroups with various degrees of c-Met expression. MET copies were increased in 4 patients. Two represented polysomy, and 2 were caused by amplification. Expression of c-Met in MET-amplified tumors was homogeneous. In conclusion, heterogeneity of c-Met expression was widely observed in GC but was not associated with the extent of expression. |
| Databáze: | OpenAIRE |
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