Isolation and structure elucidation of a novel griseorhodin
| Autor: | Aline L. Garretson, Adorjan Aszalos, Elizabeth A. Rubalcaba, James A. Chan, Ronald M. Stroshane, Peter P. Roller |
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| Rok vydání: | 1979 |
| Předmět: |
Pharmacology
Chemical Phenomena biology Strain (chemistry) Chemistry Physical Stereochemistry medicine.drug_class Antibiotics Streptomyces griseus Nuclear magnetic resonance spectroscopy biology.organism_classification Mass spectrometry In vitro Anti-Bacterial Agents Chemistry Fermentation Drug Discovery medicine Cytotoxic T cell Naphthoquinones |
| Zdroj: | The Journal of Antibiotics. 32:197-204 |
| ISSN: | 1881-1469 0021-8820 |
| Popis: | Three antibiotics possessing cytotoxic properties were isolated from a strain of Streptomyces griseus (FCRC-57). One was found to be identical with griseorhodin A. A second, FCRC-57-U, was found to be identical to griseorhodin C. FCRC-57-G is a new antibiotic structurally related to griseorhodins A and C, and is active against KB cells in vitro. The structure of this new antibiotic was determined using mass spectrometry, proton and carbon nuclear magnetic resonance spectroscopy and synthesis. |
| Databáze: | OpenAIRE |
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