Amylase level in cervical drain fluid and anastomotic leakage after cervical oesophagogastrostomy†
| Autor: | Seok Jin Haam, Hyejung Shin, Yunho Roh, Seong Yong Park, Woo Sik Yu, Joonho Jung, Dae Joon Kim, Go Eun Byun |
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| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty biology business.industry Amylase levels General Medicine Anastomosis Surgery 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Anastomotic leakage Male patient 030220 oncology & carcinogenesis White blood cell medicine biology.protein 030211 gastroenterology & hepatology Amylase Cardiology and Cardiovascular Medicine Complication business Cancer surgery |
| Zdroj: | European Journal of Cardio-Thoracic Surgery. 56:301-306 |
| ISSN: | 1873-734X 1010-7940 |
| DOI: | 10.1093/ejcts/ezz008 |
| Popis: | OBJECTIVES Anastomotic leakage after oesophageal cancer surgery is a serious complication. The purpose of this study was to evaluate the possibility of anastomotic leakage by repeatedly measuring amylase levels in the fluid obtained from the drainage tube inserted at the cervical anastomotic site. METHODS Ninety-nine patients who underwent oesophagectomy and cervical oesophagogastrostomy between April 2014 and March 2017 were retrospectively reviewed. A drainage tube was placed at the anastomotic site, and amylase levels were measured daily from postoperative day (POD) 1 until oral feeding or confirmation of anastomotic leakage. The amylase levels were analysed with a linear mixed model. RESULTS The mean age of the patients was 64.9 ± 9.0 years, and there were 89 (89%) male patients. Almost all pathologies (92%) were squamous cell carcinomas. The anastomotic methods were as follows: 63 (63%) circular stapled, 33 (33%) hand-sewn and 3 (3%) semistapled. Anastomotic leakage was confirmed in 10 (10%) patients. The amylase levels increased until POD 2 in both the leakage and non-leakage groups, but the levels subsequently decreased in the non-leakage group, whereas the levels peaked on POD 3 in the leakage group. On performing the linear mixed model analysis, anastomotic leakage was significantly associated with the trends in postoperative amylase levels in the drainage tube (P CONCLUSIONS Amylase level trends measured in the cervical drain fluid can be a useful indicator of anastomotic leakage after cervical oesophagogastrostomy. |
| Databáze: | OpenAIRE |
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