Silicon-containing water intake confers antioxidant effect, gastrointestinal protection, and gut microbiota modulation in the rodents

Autor: Pei Li Chou, Wei Yi Wu, Jyh-Chin Yang, Chiang Ting Chien
Rok vydání: 2020
Předmět:
Male
Antioxidant
Physiology
medicine.medical_treatment
Gut flora
Biochemistry
Antioxidants
Lipid peroxidation
chemistry.chemical_compound
Feces
Mice
Lactobacillus
RNA
Ribosomal
16S
Medicine and Health Sciences
Food science
Chromatography
High Pressure Liquid
Gastrointestinal tract
Multidisciplinary
biology
Chemistry
Gastrointestinal Motility Disorders
Stomach
Gastrointestinal Analysis
Chromatography
Ion Exchange
Silicon Dioxide
Glutathione
RNA
Bacterial
medicine.anatomical_structure
Bioassays and Physiological Analysis
Physiological Parameters
Medicine
Aluminum Silicates
Anatomy
Signal Transduction
Research Article
Science
Drinking
Gastroenterology and Hepatology
Gram-Positive Bacteria
Research and Analysis Methods
Gastrointestinal Agents
Gram-Negative Bacteria
Gastric mucosa
medicine
Animals
Rats
Wistar
Bacteria
Gut Bacteria
Body Weight
Organisms
Water
Biology and Life Sciences
Hydrogen Peroxide
biology.organism_classification
Lactobacillus reuteri
Gastrointestinal Microbiome
Rats
Gastrointestinal Tract
Mice
Inbred C57BL
Gastrointestinal function
Peptides
Digestive System
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0248508 (2021)
ISSN: 1932-6203
Popis: We explored the effects of silicon-containing water (BT) intake on gastrointestinal function and gut microbiota. BT was obtained by pressuring tap water through silicon minerals (mullite, Al6Si2O13) column. BT decreased H2O2chemiluminescence counts, indicating its antioxidant activity. Four weeks of BT drinking increased H2O2scavenging activity and glutathione peroxidase activity of plasma. BT drinking did not affect the body weight but significantly reduced the weight of feces and gastrointestinal motility. BT drinking significantly suppressed pylorus ligation enhanced gastric juice secretion, gastric reactive oxygen species amount, erythrocyte extravasation, IL-1β production by infiltrating leukocyte, and lipid peroxidation within gastric mucosa. Data from 16S rRNA sequencing revealed BT drinking significantly increased beneficial flora includingRuminococcaceaeUCG-005,PrevotellaceaeNK3B31,Weissella paramesenteroides,Lactobacillus reuteri, andLactobacillus murinusand decreased harmful flora includingMucispirillum,Rodentibacter, andStaphylococcus aureus. This study pioneerly provided scientific evidences for the potential effects of water-soluble forms of silicon intake on antioxidant activity, gastrointestinal function, and gut microbiota modulation.
Databáze: OpenAIRE
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