Left Atrial Function Predicts Cardiovascular Events in Patients With Chronic Heart Failure With Reduced Ejection Fraction
| Autor: | Luca Rossi, Concetta Sticozzi, Alessandro Malagoli, Giovanni Quinto Villani, Massimo F Piepoli, Francesca Bursi, Alessia Zanni |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Population 030204 cardiovascular system & hematology Ventricular Function Left 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Left atrial Internal medicine medicine Humans Radiology Nuclear Medicine and imaging In patient Heart Atria Prospective Studies Prospective cohort study education Aged Heart Failure education.field_of_study Ejection fraction business.industry Hazard ratio Reproducibility of Results Stroke Volume Atrial fibrillation Prognosis medicine.disease Echocardiography Doppler Survival Rate Italy Heart failure Cardiology Feasibility Studies Atrial Function Left Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Journal of the American Society of Echocardiography. 32:248-256 |
| ISSN: | 0894-7317 |
| Popis: | Background Heart failure (HF) is known to be the most widespread epidemic of cardiovascular disease. Among several factors with prognostic value for the clinical course of HF, left atrial (LA) function has not yet been fully examined. The aim of this prospective study was to evaluate LA function for the prediction of major cardiovascular outcomes in stable patients with chronic HF with reduced ejection fraction. Additionally, as secondary end points, cardiovascular mortality and atrial fibrillation were analyzed separately. Methods The predictive value of LA function evaluated by speckle-tracking echocardiography was assessed in a population of 286 outpatients referred to the authors’ institution for routine evaluation of chronic HF. Global peak atrial longitudinal strain was measured at the end of the reservoir phase and calculated by averaging in all LA segments. Results During a median follow-up period of 48 ± 11 months, major adverse cardiac events occurred in 98 patients (34%). In a multivariate model, global peak atrial longitudinal strain (hazard ratio, 0.95; 95% CI, 0.94–0.96; P = .02), left ventricular ejection fraction (hazard ratio, 0.95; 95% CI, 0.93–0.97; P = .01), and renal failure (hazard ratio, 0.98; 95% CI, 0.97–0.99; P = .01) were independent predictors of an adverse outcome. Sixty-six patients (23%) died of cardiac causes. Fifty-four patients (19%) developed atrial fibrillation. Patients with lower global peak atrial longitudinal strain showed worse event-free survival and developed atrial fibrillation more frequently than those with higher levels. Conclusions LA function assessed by speckle-tracking echocardiography is an independent prognostic marker in patients with HF with reduced ejection fraction. |
| Databáze: | OpenAIRE |
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