Plasma active and inactive renin and fetal complications in women with high risk pregnancies
| Autor: | Giambattista Candiani, Alberto Morganti, Esmeralda Pulazzini, Gabriella Como, Carla Sala, Massimo Cianci, Filippo Polvani, Lucia Turolo, Paola Ferraris, Gabriella Gazzano, Giancarlo Ambroso, Patrizia Quorso |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
medicine.medical_specialty Physiology Fetal Distress Inactive renin Nephropathy chemistry.chemical_compound Pregnancy Risk Factors Physiology (medical) Internal medicine Renin–angiotensin system Renin Fetal distress Prevalence Medicine Humans Aldosterone Pharmacology Fetus business.industry Obstetrics Pregnancy Outcome General Medicine medicine.disease Enzyme Activation Pregnancy Complications Endocrinology chemistry Gestation Female business |
| Zdroj: | Canadian journal of physiology and pharmacology. 69(9) |
| ISSN: | 0008-4212 |
| Popis: | To examine whether the activation of the renin system, which occurs during pregnancy, may be relevant for the development and the outcome of the fetus, we measured active and inactive renin throughout gestation in 29 women having a pregnancy defined as "high risk" because of a clinical history of hypertension, nephropathy, and unexplained abortions. In 23 of these women who delivered full-term infants with normal weight and status, we found that active renin increased progressively from early pregnancy until the end of the second trimester and then declined slightly thereafter. In contrast, in the remaining six women who had fetal complications consisting of either signs of distress requiring cesarean section or growth retardation, the increase in active renin failed to occur. In all women the levels of inactive renin were more elevated throughout gestation than those observed in nonpregnant women, and were higher, although not significantly, in women without fetal complications than in those with fetal complications. Thus, a blunted activation of the renin system during pregnancy is associated with alteration in fetal development and may possibly contribute to it.Key words: active and inactive renin, pregnancy, fetal outcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|