Prenatal alcohol exposure reduces magnetic susceptibility contrast and anisotropy in the white matter of mouse brains
| Autor: | Hui Han, Shonagh K. O'Leary-Moore, Wei Li, Kathleen K. Sulik, G. Allan Johnson, Chunlei Liu, Wei Cao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Pathology
Corpus callosum Inbred C57BL Medical and Health Sciences Myelin Mice Substance Misuse Alcohol Use and Health Neurodevelopmental disorder 2.1 Biological and endogenous factors Aetiology Pediatric White matter FASD Brain Quantitative susceptibility mapping Human brain White Matter Alcoholism medicine.anatomical_structure Diffusion Tensor Imaging Neurology Fetal Alcohol Spectrum Disorders DTI Neurological Biomedical Imaging Female Mental health Psychology medicine.medical_specialty Cognitive Neuroscience Intellectual and Developmental Disabilities (IDD) Anterior commissure Bioengineering Sensitivity and Specificity Article Clinical Research Behavioral and Social Science medicine Animals Conditions Affecting the Embryonic and Fetal Periods Fetal Alcohol Spectrum Disorders (FASD) Neurology & Neurosurgery Magnetic susceptibility anisotropy Psychology and Cognitive Sciences Neurosciences Perinatal Period - Conditions Originating in Perinatal Period medicine.disease Brain Disorders Mice Inbred C57BL Anisotropy Neuroscience Diffusion MRI |
| Zdroj: | NeuroImage, vol 102 Pt 2, iss 0 2 |
| DOI: | 10.17615/7sa8-r898 |
| Popis: | Prenatal alcohol exposure can result in long-term cognitive and behavioral deficits. Fetal alcohol spectrum disorder (FASD) refers to a range of permanent birth defects caused by prenatal alcohol exposure, and is the most common neurodevelopmental disorder in the US. Studies by autopsy and conventional structural MRI indicate that the midline structures of the brain are particularly vulnerable to prenatal alcohol exposure. Diffusion tensor imaging (DTI) has shown that abnormalities in brain white matter especially the corpus callosum are very common in FASD. Quantitative susceptibility mapping (QSM) is a novel technique that measures tissue's magnetic property. Such magnetic property is affected by tissue microstructure and molecular composition including that of myelin in the white matter. In this work, we studied three major white matter fiber bundles of a mouse model of FASD and compared it to control mice using both QSM and DTI. QSM revealed clear and significant abnormalities in anterior commissure, corpus callosum, and hippocampal commissure, which were likely due to reduced myelination. Our data also suggested that QSM may be even more sensitive than DTI for examining changes due to prenatal alcohol exposure. Although this is a preclinical study, the technique of QSM is readily translatable to human brain. |
| Databáze: | OpenAIRE |
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