Enhanced Aryltetralin Lignans Production in Linum Adventi-Tious Root Cultures
| Autor: | Roberto Consonni, Gianluca Ottolina, Roméo A Dougué Kentsop, Michela Alfieri, Iride Mascheretti, Monica Mattana, Franca Locatelli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Linum
Pharmaceutical Science Organic chemistry Analytical Chemistry Human health chemistry.chemical_compound QD241-441 Drug Discovery Botany medicine Plant defense against herbivory aryltetralin lignans 6-methoxypodophyllotoxin elicitor NMR methyl jasmonate coronatine Physical and Theoretical Chemistry Methyl jasmonate biology Coronatine biology.organism_classification Elicitor Podophyllotoxin chemistry Chemistry (miscellaneous) Molecular Medicine medicine.drug |
| Zdroj: | Molecules, Vol 26, Iss 5189, p 5189 (2021) Molecules Volume 26 Issue 17 Molecules (Basel, Online) 26 (2021). doi:10.3390/molecules26175189 info:cnr-pdr/source/autori:Alfieri M.; Mascheretti I.; Dougue Kentsop R.A.; Consonni R.; Locatelli F.; Mattana M.; Ottolina G./titolo:Enhanced aryltetralin lignans production in linum adventi-tious root cultures/doi:10.3390%2Fmolecules26175189/rivista:Molecules (Basel, Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:26 |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules26175189 |
| Popis: | Lignans are the main secondary metabolites synthetized by Linum species as plant defense molecules. They are also valuable for human health, in particular, for their potent antiviral and antineoplastic properties. In this study, the adventitious root cultures of three Linum species (L. flavum, L. mucronatum and L. dolomiticum) were developed to produce aryltetralin lignans. The effect of two elicitors, methyl jasmonate and coronatine, on aryltetralin lignans production was also evaluated. The adventitious root cultures from L. dolomiticum were obtained and analyzed for the first time and resulted as the best producer for all the aryltetralins highlighted in this system: Podophyllotoxin, 6-methoxypodophyllotoxin and 6-methoxypodophyllotoxin-7-O-β-glucoside, the last showing a productivity of 92.6 mg/g DW. The two elicitors differently affected the production of the 6-methoxypodophyllotoxin and 6-methoxypodophyllotoxin-7-O-β-glucoside. |
| Databáze: | OpenAIRE |
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