Synthesis of optically active lipopeptide analogs from the outer membrane of Escherichia coli
| Autor: | Muneaki Kurimura, Kazuo Achiwa, Masumi Takemoto |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
chemistry.chemical_classification
Stereochemistry Lipoproteins Molecular Sequence Data Lipopeptide Peptide Biological activity Stereoisomerism General Chemistry General Medicine Optically active medicine.disease_cause chemistry.chemical_compound Hydrolysis chemistry Drug Discovery Peptide synthesis medicine Escherichia coli Amino Acid Sequence Chromatography Thin Layer Mitogens Bacterial outer membrane Bacterial Outer Membrane Proteins |
| Zdroj: | Chemicalpharmaceutical bulletin. 39(10) |
| ISSN: | 0009-2363 |
| Popis: | The synthesis of optically active lipopeptide derivatives has been accomplished by the use of chiral glycerol derivatives. Lipopeptide derivatives with (R)-glycerol moieties showed higher mitogenic activities than those with the (S)-configuration. N-2, 2, 2-Trichloroethoxycarbonyl lipopeptide derivatives increased mitogenic activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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